Molecular Events Occurring in Lipophagy and Its Regulation in Flaviviridae Infection.

Frontiers in Microbiology
Keke WuJinding Chen

Abstract

Diseases caused by Flaviviridae have a wide global and economic impact due to high morbidity and mortality. Flaviviridae infection usually leads to severe, acute or chronic diseases, such as liver injury and liver cancer resulting from hepatitis C virus (HCV) infection, dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS) caused by dengue virus (DENV). Given the highly complex pathogenesis of Flaviviridae infections, they are still not fully understood at present. Accumulating evidence suggests that host autophagy is disrupted to regulate the life cycle of Flaviviridae. Organelle-specific autophagy is able to selectively target different organelles for quality control, which is essential for regulating cellular homeostasis. As an important sub process of autophagy, lipophagy regulates lipid metabolism by targeting lipid droplets (LDs) and is also closely related to the infection of a variety of pathogenic microorganisms. In this review, we briefly understand the LDs interaction relationship with Flaviviridae infection, outline the molecular events of how lipophagy occurs and the related research progress on the regulatory mechanisms of lipophagy in Flaviviridae infection. Exploring the crosstalk between viral infection...Continue Reading

References

Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·G BarbaC Bréchot
Nov 20, 2004·Science·Robert ZimmermannRudolf Zechner
Oct 17, 2006·PLoS Pathogens·Sara CherryNorbert Perrimon
Aug 28, 2007·Nature Cell Biology·Yusuke MiyanariKunitada Shimotohno
Dec 19, 2007·Journal of Viral Hepatitis·P Roingeard, C Hourioux
Jun 12, 2008·Histochemistry and Cell Biology·Toyoshi FujimotoYuki Shinohara
Apr 3, 2009·Nature·Rajat SinghMark J Czaja
May 8, 2009·Virology·Christopher RothwellL Alex Gaither
Jun 9, 2009·Autophagy·Mark J Czaja, Ana Maria Cuervo
Oct 24, 2009·PLoS Pathogens·Marcelo M SamsaAndrea V Gamarnik
Oct 27, 2009·Trends in Endocrinology and Metabolism : TEM·Gulam H SyedAleem Siddiqui
Dec 17, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Wagane J A BengaCatherine Schuster
Nov 16, 2010·Cell Host & Microbe·Nicholas S Heaton, Glenn Randall
Oct 1, 2011·The Journal of General Virology·Shanshan WangZhenghong Yuan
Dec 14, 2011·Gastroenterology·Tiziana VescovoGian Maria Fimia
Apr 27, 2012·International Journal of Cell Biology·Rajat Singh, Ana Maria Cuervo
Nov 1, 2012·Seminars in Immunopathology·M F BassendineR D G Neely
Nov 24, 2012·Journal of Virology·Roberto MateoKarla Kirkegaard
Nov 28, 2012·Cellular and Molecular Life Sciences : CMLS·Pauline FerrarisPhilippe Roingeard
Dec 1, 2012·Journal of Lipid Research·Ana Stevanovic, Christoph Thiele
Jan 29, 2013·Journal of Hepatology·Daniela PloenEberhard Hildt
Sep 10, 2013·Journal of Biomedical Science·Ying-Ray LeeHsiao-Sheng Liu
Nov 19, 2013·Chemistry & Biology·Yuki OhsakiToyoshi Fujimoto
Feb 26, 2014·World Journal of Diabetes·Sandip K Bose, Ranjit Ray
Mar 19, 2014·Protein Science : a Publication of the Protein Society·Sebastian M LambertSteve J Matthews
Dec 17, 2014·Trends in Molecular Medicine·Ana Filipe, John McLauchlan
Jan 8, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Barbara SchroederMark A McNiven
Feb 14, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Didac Carmona-GutierrezFrank Madeo
Feb 28, 2015·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Yong-Zhe ZhuZhong-Tian Qi
Mar 17, 2015·Cellular Microbiology·Caroline BarischThierry Soldati
May 12, 2015·Nature Cell Biology·Susmita Kaushik, Ana Maria Cuervo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Related Papers

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Zili ZhangShizhong Zheng
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Didac Carmona-GutierrezFrank Madeo
Bacteriologia, virusologia, parazitologia, epidemiologia
Luminiţa Popa
© 2021 Meta ULC. All rights reserved