PMID: 961499Jan 1, 1976

Molecular evidence for a viral etiology of human CNS tumors

Acta neurochirurgica
W CuaticoS Spiegelman

Abstract

The newer methods of molecular virology, including molecular hybridization and the "simultaneous detection test," were used to examine human brain tumors for evidence of RNA tumor viruses. It was found that they contained 70S RNA and RNA-directed DNA polymerase, both encapsulated in a particle possessing a density of 1.17 g/ml. These particles therefore satisfy the three diagnostic features that characterize the animal RNA tumor viruses. Of 26 of the most malignant (glioblastoma and medullo blastoma) brain tumors examined, 24 (92%) contained these virus-like entities. The possible usefulness of these particles as aids in diagnosis and monitoring therapy is briefly discussed.

References

Oct 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·W CuaticoS Spiegelman
Aug 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·W CuaticoS Spiegelman
Feb 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·R HehlmannS Spiegelman
Jul 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·R HehlmannS Spiegelman
Feb 16, 1971·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·S Spiegelman
Feb 15, 1961·Proceedings of the National Academy of Sciences of the United States of America·B D HALL, S Spiegelman

Citations

May 1, 1994·Journal of Neurosurgery·D L PetersonW E Brown
Oct 4, 2018·Bioengineering·Tara H W Dobson, Vidya Gopalakrishnan

Related Concepts

Mixed Oligoastrocytoma
Brain Tumor, Recurrent
DNA Nucleotidyltransferases
Mixed Gliomas
Melanotic Medulloblastoma
Genomic Hybridization
RNA Viruses
RNA, Viral

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