Molecular evidence for absence of Y-linkage of the Hairy Ears trait

European Journal of Human Genetics : EJHG
Andrew C LeeMark A Jobling

Abstract

The human Hairy Ears phenotype has traditionally been regarded as the only Y-linked heritable trait. Here, we use Y-chromosomal DNA binary-marker haplotyping to show that a cohort of southern Indian Hairy-Eared males carries Y chromosomes from many haplogroups of the Y-phylogeny, which, under a hypothesis of Y linkage, would require multiple independent mutations within a single population. We further show that there is no significant difference between the Y-haplogroup spectrum in Hairy-Eared males and that in a geographically matched control sample of unaffected males. The trait cannot, therefore, be Y-linked in southern Indians, and by extension, is unlikely to be so in any population.

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Citations

Apr 10, 2012·Annual Review of Genomics and Human Genetics·Jennifer F Hughes, Steve Rozen
Aug 29, 2012·Journal of Forensic Sciences·Sara H Katsanis, Jennifer K Wagner
Sep 24, 2015·Pediatric Dermatology·Enrico ValerioMario Cutrone
Jan 29, 2013·American Journal of Human Genetics·Qiuju WangChris Tyler-Smith
Aug 2, 2011·Annual Review of Genomics and Human Genetics·John Novembre, Sohini Ramachandran
Apr 22, 2008·Nature Genetics·John Novembre, Matthew Stephens
Sep 20, 2006·Nature Reviews. Genetics·David J Balding
Feb 16, 2007·Nature Reviews. Cancer·Mel Greaves
Oct 6, 2010·The Pharmacogenomics Journal·T M Baye, R A Wilke
May 24, 2008·PLoS Genetics·Garrett HellenthalDaniel Falush
Aug 31, 2017·European Journal of Human Genetics : EJHG·Akhlaq A MaanMaciej Tomaszewski

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