PMID: 8976295Jan 1, 1997Paper

Molecular evidence for pap-G specific adhesion of Escherichia coli to human renal cells

The Journal of Urology
M SöderhällJ Winberg

Abstract

To study the interaction between class II G-adhesin of Escherichia coli and human urogenital cells. The adherence of two wild type P-fimbriated E. coli strains, both carrying a class II G-adhesion, and two constructed mutants (one class II G-adhesion knock-out mutant and one class switch mutant in which the papG gene was exchanged with a prsJ96 allele which is a representative of the class III G-adhesin) to human urogenital cells were examined by light microscopy and flow cytometry. The wild type E. coli strains adhered avidly to proximal tubular cells, but the isogenic mutant strains did only adhere in one of the experiments. A soluble receptor analogue inhibited bacterial attachment. These experiments strongly suggest that the papG class II tip adhesin of P-fimbriae is essential in the pathogenesis of human kidney infection.

References

Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S J HultgrenS Normark
Jul 1, 1989·The Journal of Infection·S H JacobsonA Brauner
Aug 1, 1985·The Journal of Infectious Diseases·S H JacobsenG Källenius
Sep 1, 1987·Acta paediatrica Scandinavica·K J LidefeltS B Svenson
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·J A RobertsS Normark

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Citations

May 26, 2001·Biochemical and Biophysical Research Communications·A PramanikJ Johansson
Sep 7, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Milan Chromek, Annelie Brauner
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·R RiglerJ Wahren
Jul 29, 1998·The Journal of Urology·O T JanssonN P Wiklund
May 22, 2008·Molecular BioSystems·Ku-Lung HsuLara K Mahal

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