Molecular evidence of curcumin-induced apoptosis in the filarial worm Setaria cervi.

Parasitology Research
Ananya NayakSanti P Sinha Babu

Abstract

Curcumin (diferuloyl methane) is a major curcuminoid from Curcuma longa that exhibits various pharmacological effects and has shown multiple beneficial activities. Our understanding of its anticarcinogenic and other activities occurring through curcumin-induced apoptosis in several cancer cells has greatly expanded in recent years. Lymphatic filariasis is a worldwide health problem causing global disability in humans and is caused by filarial nematodes. Development of efficient strategies to promote programmed cell death in filarial worms remains a key challenge for anti-filarial drug developing research and a crucial unmet medical need. In this study, we have taken molecular and biochemical approaches toward understanding the molecular basis for curcumin-mediated anti-filarial activity in the filarial nematode Setaria cervi. Results of MTT assay showed that curcumin causes a significant reduction in viability of Mf and adults and thus acts as a potent macro- and micro-filaricidal agent. Hoechst staining, TUNEL staining, showed several apoptotic nuclei in different parts of curcumin-treated adults. At 25 μM concentration it showed chromosomal DNA fragmentation in adult worms. Our results indicate that curcumin decreases protein...Continue Reading

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Citations

Jul 11, 2014·Parasitology International·Prasanta SainiSanti P Sinha Babu
Feb 1, 2014·Journal of Drug Targeting·Mohammad AliIstaq Ahmad
Aug 13, 2015·Research in Veterinary Science·Bikash Ranjan Giri, Bishnupada Roy
Oct 24, 2012·Biochimica Et Biophysica Acta·Devin MorrisVishwanath Venketaraman
Dec 3, 2014·Asian Pacific Journal of Tropical Medicine·Niladri MukherjeeSanti P Sinha Babu
Feb 6, 2020·Genome Biology and Evolution·Kanchana S SenanayakeAdnan Niazi
Nov 23, 2016·PloS One·Daniela de Paula AguiarLizandra Guidi Magalhães
Sep 23, 2020·International Journal of Biological Macromolecules·Nikhilesh JoardarSanti P Sinha Babu

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