Molecular Evidence of Helicobacter Pylori Infection in Prostate Tumors.

Current Urology
Mohammed S Al-MarhoonShyam S Ganguly

Abstract

To determine whether Helicobacter pylori (H. pylori) is detectable in both benign prostatic hyperplasia (BPH) and prostate cancer (PCa). Epidemiological studies have shown significant associations between infective chronic prostatitis and prostatic carcinoma. Many bacteria have been found in the prostate of patients with chronic prostatitis, BPH, and PCa. One hundred consecutive patients with prostate diseases were enrolled in the study. Detection of H. pylori DNA in prostate tissue from patients with BPH and PCa was performed using both immunohistochemistry and PCR, and the results were confirmed by DNA sequencing. Odds ratios and the Fisher Exact test were used for the analysis of the associations between the variables. Among the patients, 78% had BPH and 19% had PCa. While immunohistochemistry showed no positive sample for H. pylori, PCR combined with sequencing detected H. pylori DNA in prostate tissue samples from 5 patients. However, statistical analysis of the data showed that BPH and PCa are not significantly associated with the presence of H. pylori DNA in prostate tissue (odds ratio = 0.94, 95% confidence interval = 0.09-23.34, one-tailed Chi-square value = 0.660, p > 0.05). The limitation of this study was the small ...Continue Reading

Citations

Feb 23, 2019·Carcinogenesis·Sagarika BanerjeeErle S Robertson
Jan 29, 2020·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Holger Brüggemann, Munir A Al-Zeer
Jul 2, 2020·Frontiers of Medicine·Solmaz Ohadian Moghadam, Seyed Ali Momeni
Feb 19, 2020·Molecular Genetics & Genomic Medicine·Abolfazl Zendehdel, Maryam Roham
Nov 6, 2020·Cancer Research·Sheetal Parida, Dipali Sharma
Jul 17, 2021·Prostate Cancer and Prostatic Diseases·Juan Javier-DesLogesJ Kellogg Parsons

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