Molecular evidence of HTLV-II subtype B among an urban population living in South Brazil

AIDS Research and Human Retroviruses
Jane Dagmar Pollo RennerVirgínia Minghelli Schmitt

Abstract

Human T cell lymphotropic virus type II (HTLV-II) is a deltaretrovirus endemic in Indian populations living in Central and South America, among Pygmies tribes from Central Africa, and epidemic among injecting drug users (IDUs) in the United States, Europe, Southeast Asia, and South America. To date only the HTLV-IIa subtype has been demonstrated among Brazilians (Amazon basin Indians, blood donors, and IDUs). We analyzed HTLV-II isolates from 12 individuals living in the urban area of Porto Alegre, Southern Brazil, identified as seropositive for HTLVI/II in a blood donation. The HTLV-II long terminal repeat (LTR) region was sequenced and compared with nucleotide sequences of isolates HTLV-IIa (Mo), HTLV-IIb (NRA) prototypes. Phylogenetic analysis of the LTR region demonstrated that seven new isolates clustered together with American Indians HTLV-IIb isolates, and five new HTLV-IIa isolates clustered within the HTLV-IIa Brazilian subgroup, named the HTLV-IIc subtype. Both HTLV-IIa and IIb seem to be endemic in the urban area of Porto Alegre, South of Brazil, and could have reached this region via the Amazon basin and the Pacific Coast ancient human migratory pathways. To our knowledge this is the first study demonstrating the pr...Continue Reading

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Citations

Oct 14, 2010·AIDS Research and Human Retroviruses·Mariana Cavalheiro MagriAdele Caterino-de-Araujo
Mar 15, 2013·AIDS Research and Human Retroviruses·Mariana Cavalheiro MagriAdele Caterino-de-Araujo
Sep 8, 2007·Revista Do Instituto De Medicina Tropical De São Paulo·Helena Kaminami MorimotoAdele Caterino-de-Araujo
May 24, 2019·BMC Infectious Diseases·Isabel Luís Jocene BraçoAntonio Carlos Rosário Vallinoto
Aug 18, 2009·Revista Da Sociedade Brasileira De Medicina Tropical·Ethienne Lobato dos SantosAntonio Carlos Rosário Vallinoto
Sep 16, 2017·Frontiers in Microbiology·Ricardo IshakAntonio C R Vallinoto
Feb 16, 2020·Retrovirology·Ricardo IshakAntonio Carlos R Vallinoto
Nov 3, 2020·Virus Evolution·Ricardo IshakAntonio Carlos Rosário Vallinoto
Mar 18, 2021·Epidemiologia E Serviços De Saúde : Revista Do Sistema Unico De Saúde Do Brasil·Carolina RosadasRicardo Ishak
May 20, 2021·Revista Da Sociedade Brasileira De Medicina Tropical·Carolina RosadasRicardo Ishak

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