Molecular evidence that Heligmosomoides polygyrus from laboratory mice and wood mice are separate species

Parasitology
J CableJerzy Behnke

Abstract

The gastro-intestinal (GI) nematode Heligmosomoides polygyrus is an important experimental model in laboratory mice and a well-studied parasite of wood mice in the field. Despite an extensive literature, the taxonomy of this parasite in different hosts is confused, and it is unclear whether laboratory and field systems represent the same or different Operational Taxonomic Units (OTUs). Molecular analyses reveal high sequence divergence between H. p. bakeri (laboratory) and H. p. polygyrus (field); 3% difference in the ribosomal DNA Internal Transcribed Spacers (ITS) and 8.6% variation in the more rapidly evolving mitochondrial cytochrome c oxidase I (COI) gene. The COI sequence of U.K. H. p. polygyrus is more similar to H. glareoli from voles than to H. p. bakeri, while a single isolate of H. p. polygyrus from Guernsey confirms the extent of genetic variation between H. p. polygyrus populations. Analysis of molecular variance demonstrated that mtCOI sequence variation is associated primarily with groups with distinct ITS2 sequences, and with host identity, but is not partitioned significantly with a single combined taxon H. polygyrus incorporating European and North American isolates. We conclude therefore that the laboratory O...Continue Reading

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Citations

Oct 12, 2012·Seminars in Immunopathology·Lisa A ReynoldsRick M Maizels
Nov 29, 2007·Journal of Helminthology·L M M AlkazmiJ M Behnke
Sep 3, 2008·Parasites & Vectors·Jerzy M BehnkeIan R Duce
May 3, 2011·Trends in Parasitology·Nicola L Harris
Dec 17, 2010·Trends in Immunology·Nicola Harris, William C Gause
Aug 24, 2010·Trends in Parasitology·Jerzy Behnke, Phil D Harris
Mar 31, 2015·International Journal for Parasitology·Sarah A BudischakVanessa O Ezenwa
Dec 17, 2010·Trends in Parasitology·Rick M MaizelsWilliam C Gause
Aug 31, 2011·Experimental Parasitology·Rick M MaizelsKatherine A Smith
Feb 11, 2015·International Journal for Parasitology·Spiridoula AthanasiadouJos G M Houdijk
Dec 29, 2017·Journal of Helminthology·D Rollinson
Feb 21, 2018·Frontiers in Immunology·Simon A BabayanAmy B Pedersen
Mar 30, 2019·International Journal for Parasitology. Parasites and Wildlife·Melanie ClercAmy B Pedersen
Jan 21, 2021·Proceedings. Biological Sciences·Amy R SweenyAmy B Pedersen
Jul 8, 2019·Experimental Parasitology·Sarah R GomezDeborah M Kristan
Aug 21, 2021·Journal of Helminthology·M Musah-ErojeJ M Behnke

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