Molecular Evolution and Functional Divergence of the IgLON Family

Evolutionary Bioinformatics Online
Norwin KubickMichel-Edwar Mickael

Abstract

IgLON family is a subgroup of cell adhesion molecules which is known to have diverse roles in neuronal development. IgLONs are characterized by possessing 3 Ig-like C2 domains, which play a part in mediating various cellular interactions. Recently, IgLONs have been shown to be expressed at the blood-brain barrier (BBB). However, our understanding of the genetic divergence patterns and evolutionary rates of these proteins in relation to their functions, in general, and at the BBB, in particular, remains inadequate. In this study, 12 species were explored to shed more light on the phylogenetic origins, structure, functional specificity, and divergence of this family. A total of 40 IgLON genes were identified from vertebrates and invertebrates. The absence of IgLON family genes in Hydra vulgaris and Nematostella vectensis but not in Drosophila melanogaster suggests that this family appeared during the time of divergence of Arthropoda 455 Mya. In general, IgLON genes have been subject to strong positive selection in vertebrates. Our study, based on IgLONs' structural similarity, suggests that they may play a role in the evolutionary changes in the brain anatomy towards complexity including regulating neural growth and BBB permeabil...Continue Reading

Citations

Sep 20, 2020·Pharmaceutics·Norwin KubickMichel-Edwar Mickael
Oct 22, 2019·Frontiers in Neurology·Mette Scheller Nissen, Morten Blaabjerg

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Methods Mentioned

BETA
RNA-Seq

Software Mentioned

MAFFT
IgLON
DIVERGE
ProtTest
SDPpred
Seaview
PolyPhen
NTM
PHYML
BLASTP

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