PMID: 8587122Dec 1, 1995Paper

Molecular evolution and secondary structural conservation in the B-cell lymphoma leukemia 2 (bcl-2) family of proto-oncogene products

Journal of Molecular Evolution
D L Evans, R E Mansel

Abstract

The nature of the bcl-2 family of proto-oncogenes was analyzed by sequence alignment, secondary structure prediction, and phylogenetic techniques. Phylogenies were inferred from both the nucleic acid and amino acid sequences of the human, murine, rat, and chicken sequences for BCL-2 and BCL-X, human MCL1, murine A1, the nematode Caenorhabditis elegans and Caenorhabditis briggsiae ced-9 proteins, and the sequences BHRF1 from Epstein-Barr and LMW5-HL from African swine fever viruses. Both sequence alignment and secondary structure prediction techniques supported the conservation of both the overall secondary structure and the carboxy-terminal transmembrane domain in all members of the family. All the treeing methods employed (distance matrix, maximum likelihood, and parsimony) supported a tree in which the proapoptotic proteins BCL-2 and BCL-X represent the most recent additions to the group. All the trees also indicated that the viral proteins BHRF1 and LMW-HL arose from a common ancestor, an ancestor they shared in common with the pro-apoptotic control protein BAX, indicating that this function of BAX evolved only recently. The most ancient branches are represented by the nematode ced-9 protein and by the control genes MCL1 and...Continue Reading

Citations

Jan 1, 1997·Immunologic Research·T W Behrens, D L Mueller
Sep 10, 2003·Hematology/oncology Clinics of North America·Gustavo Rodriguez
Jan 1, 1997·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·M DionL F Brisson
Apr 15, 2000·The Journal of Biological Chemistry·C D BingleM K Whyte

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