Molecular evolution of dengue 2 virus in Puerto Rico: positive selection in the viral envelope accompanies clade reintroduction

The Journal of General Virology
Shannon N BennettW Owen McMillan

Abstract

Dengue virus is a circumtropical, mosquito-borne flavivirus that infects 50-100 million people each year and is expanding in both range and prevalence. Of the four co-circulating viral serotypes (DENV-1 to DENV-4) that cause mild to severe febrile disease, DENV-2 has been implicated in the onset of dengue haemorrhagic fever (DHF) in the Americas in the early 1980s. To identify patterns of genetic change since DENV-2's reintroduction into the region, molecular evolution in DENV-2 from Puerto Rico (PR) and surrounding countries was examined over a 20 year period of fluctuating disease incidence. Structural genes (over 20 % of the viral genome), which affect viral packaging, host-cell entry and immune response, were sequenced for 91 DENV-2 isolates derived from both low- and high-prevalence years. Phylogenetic analyses indicated that DENV-2 outbreaks in PR have been caused by viruses assigned to subtype IIIb, originally from Asia. Variation amongst DENV-2 viruses in PR has since largely arisen in situ, except for a lineage-replacement event in 1994 that appears to have non-PR New World origins. Although most structural genes have remained relatively conserved since the 1980s, strong evidence was found for positive selection acting...Continue Reading

References

May 1, 1978·The American Journal of Tropical Medicine and Hygiene·D J GublerJ R Hitchcock
Apr 1, 1989·The American Journal of Tropical Medicine and Hygiene·S C KliksD S Burke
Jan 1, 1985·Journal of Molecular Evolution·M HasegawaT Yano
Jan 1, 1994·Archives of Virology·V VorndamD W Trent
Nov 1, 1993·Virology·J A LewisD W Trent
Oct 1, 1996·Health Affairs·W P Welch
May 1, 1997·The American Journal of Tropical Medicine and Hygiene·S TheinJ Aaskov
Aug 1, 1997·Nature Medicine·J R PutnakB L Innis
Nov 21, 1997·Computer Applications in the Biosciences : CABIOS·Z Yang
Feb 6, 1998·The American Journal of Tropical Medicine and Hygiene·R Rico-HesseF A Ennis
Apr 1, 1998·Bioinformatics·D H Huson
Jul 17, 1998·Clinical Microbiology Reviews·D J Gubler
May 11, 1999·Journal of Virology·K C LeitmeyerR Rico-Hesse
Feb 16, 2000·The American Journal of Tropical Medicine and Hygiene·C A SariolM G Guzman
Mar 9, 2000·Journal of Virology·E WangS C Weaver
Jun 27, 2001·The American Journal of Tropical Medicine and Hygiene·J G Rigau-PérezG G Clark
Sep 20, 2001·The American Journal of Tropical Medicine and Hygiene·S B HalsteadD M Watts
Dec 18, 2001·Science·J P HuelsenbeckJ P Bollback
Jun 21, 2002·The Journal of General Virology·S Susanna TwiddyEdward C Holmes
Mar 7, 2003·Virology·Jerome E FosterChristine V F Carrington
Mar 14, 2003·Journal of Virology·Raymond Cologna, Rebeca Rico-Hesse
Jul 2, 2003·Molecular Biology and Evolution·Shannon N BennettW Owen McMillan
Aug 13, 2003·Bioinformatics·Fredrik Ronquist, John P Huelsenbeck
Dec 19, 2003·Nucleic Acids Research·Dennis A BensonDavid L Wheeler
Jan 23, 2004·Nature·Yorgo ModisStephen C Harrison

❮ Previous
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Citations

Jun 2, 2007·Journal of Molecular Evolution·Eleca J Dunham, Edward C Holmes
Nov 1, 2012·Epidemiology and Infection·E HuhtamoN Y Uzcátegui
Feb 10, 2012·Molecular Biology and Evolution·Orchid M AllicockChristine V F Carrington
Oct 19, 2011·Nucleic Acids Research·Brett E PickettRichard H Scheuermann
Feb 13, 2009·Journal of Virology·Mark J SchreiberMartin L Hibberd
Dec 2, 2011·Journal of Virology·Louis LambrechtsThomas W Scott
Apr 24, 2008·Annual Review of Microbiology·Jennifer L Kyle, Eva Harris
Jul 11, 2009·BMC Evolutionary Biology·Louis LambrechtsThomas W Scott
Dec 17, 2009·BMC Microbiology·Gerardo Perez-RamirezMaria de Lourdes Munoz
Sep 15, 2010·Virology Journal·Jairo A MendezJuan C Gallego-Gomez
Mar 13, 2012·Virology Journal·Jairo A MéndezJuan C Gallego-Gomez
May 30, 2009·PLoS Neglected Tropical Diseases·Adriano MondiniMaurício Lacerda Nogueira
Dec 3, 2010·PLoS Neglected Tropical Diseases·José Lourenço, Mario Recker
Mar 22, 2013·PLoS Neglected Tropical Diseases·Nieli Rodrigues da Costa FariaFlavia Barreto dos Santos
Apr 18, 2013·PLoS Neglected Tropical Diseases·Tyler M SharpKay M Tomashek
Apr 20, 2014·PLoS Neglected Tropical Diseases·Marcio R T NunesW Ian Lipkin
May 15, 2013·PloS One·Christian Julian Villabona-ArenasMaurício L Nogueira
Feb 6, 2009·Emerging Infectious Diseases·Nalaka KanakaratneMaya Gunasekera
Mar 6, 2010·Emerging Infectious Diseases·Michelli Faria OliveiraRita Maria Ribeiro Nogueira
Jan 5, 2011·Emerging Infectious Diseases·Kate L McElroyJorge L Muñoz-Jordán
Oct 14, 2011·Viruses·Rubing Chen, Nikos Vasilakis
Jan 1, 2010·Bioinformation·Usman Sumo Friend Tambunan, Samira Alamudi
Jun 16, 2010·Archives of Virology·Erik Carrillo-ValenzoJosé Ramos-Castañeda
Jul 16, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Veasna DuongPhilippe Buchy
Sep 14, 2010·International Journal of Antimicrobial Agents·Alfonso Guzman, Raul E Istúriz
Jan 29, 2014·Trends in Microbiology·Jane P MessinaSimon I Hay
May 8, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Cristhopher D CruzEric S Halsey
Jan 10, 2012·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Raquel L CostaCarlos G Schrago
Nov 1, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Kim-Sung LeeLee-Ching Ng
Jun 3, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·J A PatilD Cecilia

❮ Previous
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