PMID: 8587131Dec 1, 1995Paper

Molecular evolution of group II phospholipases A2

Journal of Molecular Evolution
T OgawaM Ohno

Abstract

The nucleotide sequences of 13 cDNAs encoding group II phospholipases A2 (PLA2s), which are from viperidae snake venoms and from mammalian sources, were aligned and analyzed by phylogenetic trees constructed using various components of the sequences. The evolutionary trees derived from the combined sequences of the untranslated (5' and 3') region and the signal peptide region of cDNAs were in accord with the consequences from taxonomy. In contrast, the evolutionary trees from the mature protein-coding region sequences of cDNAs and from the amino acid sequences showed random patterns. These observations indicated that the mature protein-coding region has evolved through a process differently from the untranslated and signal peptide regions. The trees built from the nucleotide differences at each of three positions of codons in the mature protein-coding region suggested that snake-venom-gland PLA2 genes have evolved via a process different from mammalian PLA2 genes. The occurrence of accelerated evolution has been recently discovered in Trimeresurus flavoviridis venom-gland group II PLA2 isozyme genes (Nakashima et al. 1993, Proc Natl Acad Sci USA 90:5964-5968), so the present phylogenetic analysis together with the estimation of...Continue Reading

Citations

Dec 1, 1995·Toxicon : Official Journal of the International Society on Toxinology·T OgawaM Ohno
Mar 17, 2004·Toxicon : Official Journal of the International Society on Toxinology·Motonori OhnoShosaku Hattori
Mar 17, 2004·Toxicon : Official Journal of the International Society on Toxinology·Sergio LizanoJonas Perales
Mar 17, 2004·Toxicon : Official Journal of the International Society on Toxinology·Bruno LomonteLeonel Calderón
May 7, 2005·Toxicon : Official Journal of the International Society on Toxinology·Ken-ichi SaguchiShigesada Higuchi
Aug 11, 2000·Toxicon : Official Journal of the International Society on Toxinology·D Mebs
Aug 15, 2002·Toxicon : Official Journal of the International Society on Toxinology·Ayako TaniMotonori Ohno
Jan 27, 1999·Toxicon : Official Journal of the International Society on Toxinology·B LomonteJ M Gutiérrez
Mar 18, 1999·Toxicon : Official Journal of the International Society on Toxinology·C L OwnbyJ E Fletcher
Jan 23, 1999·European Journal of Biochemistry·A Alape-GirónH Jörnvall
Oct 2, 2007·Toxicon : Official Journal of the International Society on Toxinology·Virginie M JanValérie Choumet
Jan 9, 2007·Toxicon : Official Journal of the International Society on Toxinology·Daniela C S DamicoCarla B Collares-Buzato
Dec 8, 2004·Toxicon : Official Journal of the International Society on Toxinology·Tomohisa OgawaMotonori Ohno
Jul 31, 2004·Toxicon : Official Journal of the International Society on Toxinology·Isac de CastroLuis Yu
Aug 16, 2000·Molecular Phylogenetics and Evolution·A Malhotra, R S Thorpe
Jul 21, 1998·Molecular Phylogenetics and Evolution·N Vidal, G Lecointre
Feb 13, 2001·Gene·D Kordis, F Gubensek
Jul 11, 2007·Journal of Mass Spectrometry : JMS·Juan J CalveteLibia Sanz
Sep 30, 2008·Molecular Biology and Evolution·Mayako KutsukakeTakema Fukatsu
Mar 18, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Summer Xia HanR Manjunatha Kini
Nov 11, 2006·Molecular Diversity·Toru Tamiya, Takahiko J Fujimi
Jun 19, 2008·Journal of Proteome Research·Alberto Alape-GirónJuan J Calvete
Sep 2, 2006·Journal of Proteome Research·Libia SanzJuan J Calvete

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
K NakashimaShosaku Hattori
Proceedings of the National Academy of Sciences of the United States of America
K NakashimaM Ohno
Proceedings of the National Academy of Sciences of the United States of America
T OgawaM Ohno
© 2021 Meta ULC. All rights reserved