PMID: 7932787Sep 1, 1994Paper

Molecular evolution of interleukin-3

Journal of Molecular Evolution
H BurgerL C Dorssers

Abstract

Chimpanzee, tamarin, and marmoset interleukin-3 (IL-3) genes were cloned, sequenced, and expressed. Western blot analysis demonstrated that functional genes were isolated. IL-3 sequences were compared with those of mouse, rat, rhesus monkey, gibbon, and man. Multiple alignment of the IL-3 coding regions showed that only a few regions had been conserved during mammalian evolution, which are likely associated with functional domains of the IL-3 protein. Substitution rates for the various lineages were calculated and the numbers of synonymous and nonsynonymous substitutions were estimated separately. Distance matrices of the IL-3 coding regions were used to construct phylogenetic trees which revealed large differences in IL-3 evolution rate as well as a more rapid substitution rate for rodents and a rate slowdown during hominoid evolution. Extremes were rhesus monkey IL-3, which accumulated few synonymous substitutions, and gibbon IL-3, which had almost exclusively synonymous substitutions. In rhesus monkey IL-3, nonsynonymous substitutions outnumbered synonymous substitutions, which could not be readily explained by a random process of substitutions. We assume that during evolution of IL-3, the majority of the amino acid replacem...Continue Reading

References

Feb 20, 1975·Nature·M GoodmanG Matsuda
Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A F LopezM A Vadas
May 1, 1992·International Journal of Cell Cloning·A Miyajima
Jan 1, 1990·International Archives of Allergy and Applied Immunology·R D MergetJ Meier-Sydow
Mar 1, 1990·Journal of Molecular Evolution·M GoodmanJ L Slightom
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J F Bazan
Nov 25, 1990·Nucleic Acids Research·H BurgerG Wagemaker
Jan 1, 1990·Biotherapy·G WagemakerJ J Wielenga
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·W H LiY W Yang
Mar 5, 1987·Journal of Molecular Biology·T E Creighton, I G Charles
Aug 1, 1989·Journal of Molecular Evolution·S R Palumbi
Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J P ShawC K Shen
May 12, 1986·Nucleic Acids Research·D R CohenI G Young
Jan 1, 1987·Journal of Molecular Evolution·E Zuckerkandl
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M M MiyamotoM R Tennant
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·I Clark-LewisS B Kent
Jun 5, 1987·Science·S C Clark, R Kamen
Jan 1, 1987·Cold Spring Harbor Symposia on Quantitative Biology·M GoodmanJ L Slightom
Oct 29, 1971·Nature·M GoodmanG W Moore
Jan 20, 1967·Science·W M Fitch, E Margoliash
Feb 17, 1968·Nature·M Kimura
Jan 19, 1984·Nature·M C FungI G Young
Mar 1, 1984·Scientific American·D Pilbeam
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·T MiyataT Nishida
Jul 1, 1993·Journal of Molecular Evolution·M Wallis
Mar 1, 1994·Biochimica Et Biophysica Acta·H BurgerL C Dorssers

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