PMID: 9189641Jan 1, 1997Paper

Molecular evolution of multiply-antibiotic-resistant staphylococci

Ciba Foundation Symposium
R A Skurray, Neville Firth

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is an intractable nosocomial pathogen. The chemotherapeutic intransigence of this organism stems from its predilection to antimicrobial resistance as a consequential response to selective pressures prevailing in the clinical environment. MRSA isolates are frequently resistant to all practicable antimicrobials except the glycopeptide, vancomycin. Although antimicrobial resistance sometimes arises via chromosomal mutation, the emergence of multiply-antibiotic-resistant staphylococci is primarily due to the acquisition of pre-existent resistance genes; such determinants can be encoded chromosomally or by plasmids and are often associated with transposons or insertion sequences. Clinical staphylococci commonly carry one or more plasmids, ranging from small replicons that are phenotypically cryptic or contain only a single resistance gene, to larger episomes that possess several such determinants and sometimes additionally encode systems that mediate their own conjugative transmission and the mobilization of other plasmids. The detection of closely related plasmids, elements and/or genes in other hosts, including coagulase-negative staphylococci and enterococci, attests to interspec...Continue Reading

Citations

Sep 2, 2010·Microbiology and Molecular Biology Reviews : MMBR·Julian Davies, Dorothy Davies
Apr 15, 2003·Clinical Microbiology Reviews·Peter Gilbert, Andrew J McBain
Dec 15, 2018·Microbiology Spectrum·Neville FirthJoshua P Ramsay

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