PMID: 9545469Jun 6, 1998Paper

Molecular evolution of the globin gene cluster E in two distantly related midges, Chironomus pallidivittatus and C. thummi thummi

Journal of Molecular Evolution
T HankelnE R Schmidt

Abstract

We have studied the evolutionary dynamics of a cluster of insect globin genes by comparing the organization and sequence of the gene group in two distantly related species, Chironomus pallidivittatus and C. t. thummi. Although the general architecture of the globin gene cluster has been conserved, we have found an additional, previously undescribed gene (named Cpa F) in C. pallidivittatus which shows signs of accelerated sequence evolution at nonsynonymous codon positions. This new gene is clearly functional, as demonstrated by Northern analysis. Comparison of paralogous and orthologous genes reveals patterns of intraspecific sequence homogenization. The head-to-head-oriented globin 3 and 4 gene pairs in C. t. thummi and the gb 4 gene pair in C. pallidivittatus have been efficiently homogenized, probably by gene conversion, in their promoter and coding regions. Inverted transcriptional orientation seems to favor efficient conversion. The orthologous genes from C. t. thummi and C. pallidivittatus reveal different levels of sequence conservation, ranging from 85.3 to 94.7% amino acid identity. Surprisingly, globin gene E, for which up to now no corresponding protein has been detected in the larval hemolymph of C. t. thummi, shows...Continue Reading

Citations

Sep 9, 2011·Molecular Genetics and Genomics : MGG·Giampaolo ZampicininiGabriella Sella
Apr 13, 2000·Annual Review of Entomology·M S CaterinoF A Sperling
Dec 2, 2010·BMC Evolutionary Biology·Bettina EbnerThomas Hankeln
May 12, 2012·Insect Biochemistry and Molecular Biology·Agnes WawrowskiThorsten Burmester
Feb 17, 2007·Journal of Insect Physiology·Thorsten Burmester, Thomas Hankeln
Jan 22, 2009·Evolution; International Journal of Organic Evolution·Jeffrey L Feder, Sebastian Velez
Jul 2, 2015·Integrative and Comparative Biology·Thorsten Burmester
May 26, 2015·Zoological Science·Richard CornetteTakashi Okuda
Jun 6, 2002·The Journal of Biological Chemistry·Thomas HankelnThorsten Burmester
May 27, 2005·The Journal of Biological Chemistry·Daniele de SanctisMartino Bolognesi
Jun 6, 2020·PloS One·Hollister W HerholdDavid A Grimaldi
Sep 15, 2020·Frontiers in Genetics·Andreas ProthmannThomas Hankeln
Mar 29, 2001·Physiological Reviews·R E Weber, S N Vinogradov

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