PMID: 8587121Dec 1, 1995Paper

Molecular evolution of the histidine biosynthetic pathway

Journal of Molecular Evolution
Renato FaniA Lazcano

Abstract

The available sequences of genes encoding the enzymes associated with histidine biosynthesis suggest that this is an ancient metabolic pathway that was assembled prior to the diversification of the Bacteria, Archaea, and Eucarya. Paralogous duplications, gene elongation, and fusion events involving different his genes have played a major role in shaping this biosynthetic route. Evidence that the hisA and the hisF genes and their homologous are the result of two successive duplication events that apparently took place before the separation of the three cellular lineages is extended. These two successive gene duplication events as well as the homology between the hisH genes and the sequences encoding the TrpG-type amidotransferases support the idea that during the early stages of metabolic evolution at least parts of the histidine biosynthetic pathway were mediated by enzymes of broader substrate specificities. Maximum likelihood trees calculated for the available sequences of genes encoding these enzymes have been obtained. Their topologies support the possibility of an evolutionary proximity of archaebacteria with low GC Gram-positive bacteria. This observation is consistent with those detected by other workers using the sequen...Continue Reading

Citations

Aug 4, 1999·Proceedings of the National Academy of Sciences of the United States of America·M SisslerC Francklyn
Apr 29, 2004·BMC Bioinformatics·Sara Light, Per Kraulis
Feb 24, 2001·Genome Biology·J A Gerlt, P C Babbitt
May 26, 2009·Research in Microbiology·Marco FondiRenato Fani
Jan 8, 2009·Physics of Life Reviews·Renato Fani, Marco Fondi
Sep 23, 2003·Protein Science : a Publication of the Protein Society·Keiko MatsudaNobuhiro Go
Apr 26, 2005·Biophysical Journal·Rommie E AmaroZaida A Luthey-Schulten
May 5, 2005·Journal of Molecular Evolution·Renato FaniPietro Liò
Mar 4, 2000·Genome Génome / Conseil National De Recherches Canada·R L CharleboisC W Sensen
Feb 23, 1999·Microbial & Comparative Genomics·T Gaasterland, M A Ragan
May 18, 2020·Microorganisms·Sara Del DucaRenato Fani
Dec 31, 1997·Microbiology and Molecular Biology Reviews : MMBR·J R Brown, W F Doolittle
Apr 14, 2021·Annual Review of Plant Biology·Hiroshi A Maeda, Alisdair R Fernie

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