Molecular evolution of the keratin associated protein gene family in mammals, role in the evolution of mammalian hair.

BMC Evolutionary Biology
Dong-Dong WuYa-Ping Zhang

Abstract

Hair is unique to mammals. Keratin associated proteins (KRTAPs), which contain two major groups: high/ultrahigh cysteine and high glycine-tyrosine, are one of the major components of hair and play essential roles in the formation of rigid and resistant hair shafts. The KRTAP family was identified as being unique to mammals, and near-complete KRTAP gene repertoires for eight mammalian genomes were characterized in this study. An expanded KRTAP gene repertoire was found in rodents. Surprisingly, humans have a similar number of genes as other primates despite the relative hairlessness of humans. We identified several new subfamilies not previously reported in the high/ultrahigh cysteine KRTAP genes. Genes in many subfamilies of the high/ultrahigh cysteine KRTAP genes have evolved by concerted evolution with frequent gene conversion events, yielding a higher GC base content for these gene sequences. In contrast, the high glycine-tyrosine KRTAP genes have evolved more dynamically, with fewer gene conversion events and thus have a lower GC base content, possibly due to positive selection. Most of the subfamilies emerged early in the evolution of mammals, thus we propose that the mammalian ancestor should have a diverse KRTAP gene rep...Continue Reading

References

Dec 26, 1991·Annals of the New York Academy of Sciences·B C PowellG E Rogers
May 1, 1981·American Journal of Physical Anthropology·G G Schwartz, L A Rosenblum
Nov 18, 1993·Nature·S J Gould, N Eldredge
Sep 1, 1997·Nucleic Acids Research·S F AltschulD J Lipman
Nov 21, 1997·Computer Applications in the Biosciences : CABIOS·Z Yang
Oct 3, 1998·The Journal of Biological Chemistry·M A RogersJ Schweizer
Jul 3, 1999·The Journal of Biological Chemistry·L LangbeinJ Schweizer
Feb 26, 2000·The Journal of Investigative Dermatology·M A RogersJ Schweizer
Mar 10, 2001·Nature·E S LanderUNKNOWN International Human Genome Sequencing Consortium
Sep 5, 2002·Nature Reviews. Immunology·Martin F Flajnik
Sep 14, 2002·The Journal of Biological Chemistry·Yutaka ShimomuraMasaaki Ito
Dec 6, 2002·Nature·UNKNOWN Mouse Genome Sequencing ConsortiumEric S Lander
Jan 28, 2003·Trends in Genetics : TIG·Nicolas Galtier
Apr 8, 2003·Molecular Biology and Evolution·Peng ShiYa-Ping Zhang
Apr 30, 2003·Molecular Biology and Evolution·Michael S RosenbergSudhir Kumar
Jun 13, 2003·Trends in Genetics : TIG·Gabriel Marais
Jun 26, 2003·Experimental Dermatology·P F A Maderson
Sep 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yoshihito Niimura, Masatoshi Nei
Feb 14, 2004·The Journal of Investigative Dermatology·Michael A RogersJürgen Schweizer
Mar 3, 2004·Genome Research·James P NoonanRichard M Myers
Mar 23, 2004·Nature Reviews. Neuroscience·Peter Mombaerts
Apr 2, 2004·Nature·Richard A GibbsUNKNOWN Rat Genome Sequencing Project Consortium
Apr 17, 2004·European Journal of Cell Biology·Michael HesseThomas M Magin
May 18, 2004·Biochemical and Biophysical Research Communications·Shoichi YahagiNobuyoshi Shimizu
Jul 21, 2004·Briefings in Bioinformatics·Sudhir KumarMasatoshi Nei
Sep 21, 2004·Bioinformatics·D P MartinD Posada
Oct 7, 2004·Proceedings of the National Academy of Sciences of the United States of America·Christopher M ParryJohannes le Coutre
Oct 22, 2004·Molecular Biology and Evolution·Anne FischerSvante Pääbo
Mar 26, 2005·Proceedings of the National Academy of Sciences of the United States of America·Wendy E GrusJianzhi Zhang
Apr 13, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yoshihito Niimura, Masatoshi Nei
Jun 16, 2005·The Journal of Investigative Dermatology·Naoyuki KariyaMasaaki Ito
Jul 7, 2005·The Journal of Investigative Dermatology·Michael A Rogers, Jürgen Schweizer
Sep 2, 2005·Nature·UNKNOWN Chimpanzee Sequencing and Analysis Consortium
Oct 7, 2005·Molecular Biology and Evolution·Peng Shi, Jianzhi Zhang
Nov 16, 2005·Annual Review of Genetics·Masatoshi Nei, Alejandro P Rooney

❮ Previous
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Citations

Sep 1, 2010·Animal : an International Journal of Animal Bioscience·H Galbraith
Nov 3, 2011·Molecular Biology and Evolution·Wim Vandebergh, Franky Bossuyt
Nov 13, 2010·Pigment Cell & Melanoma Research·Desmond J Tobin
Jun 17, 2011·BMC Evolutionary Biology·David M IrwinCaro-Beth Stewart
Sep 15, 2009·BMC Evolutionary Biology·Alfred L RocaAlex D Greenwood
Nov 26, 2009·BMC Genomics·Mathieu GautierJean-Louis Foulley
Feb 3, 2012·International Journal of Biological Sciences·Hua GongJonathan G H Hickford
May 27, 2014·Genome Biology and Evolution·Athanasia Pavlopoulou, Andreas Scorilas
Apr 13, 2012·The Journal of Investigative Dermatology·Hiroki FujikawaYutaka Shimomura
Nov 28, 2015·Genetics, Selection, Evolution : GSE·Sithembile O MakinaAzwihangwisi Maiwashe
Sep 8, 2011·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Matthew J Greenwold, Roger H Sawyer
Jun 8, 2013·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Matthew J Greenwold, Roger H Sawyer
Jan 1, 2014·International Journal of Dermatology·Barbara BuffoliLuigi F Rodella
Jul 15, 2015·Acta Biomaterialia·Amir Hossein RajabiTreena Livingston Arinzeh
May 8, 2015·BMC Evolutionary Biology·Bettina StrasserLeopold Eckhart
Jun 12, 2013·Computers in Biology and Medicine·Amit Kumar BanerjeeV Lakshmi Prasanna
May 31, 2016·Genes·Hua GongJon G H Hickford
Oct 30, 2012·Experimental Biology and Medicine·Arthit TolekSopit Wongkham
Mar 21, 2017·International Journal of Biological Macromolecules·Célia F CruzArtur Cavaco-Paulo
Jan 24, 2012·Evolutionary Bioinformatics Online·Benjamin LinardJulie D Thompson
Jan 26, 2017·Proceedings. Biological Sciences·Alison E MoyerMary H Schweitzer
Nov 15, 2019·PLoS Genetics·Jingtao LilueThomas M Keane
Dec 17, 2019·PloS One·Sachiko KoyamaAnthony Mescher
Feb 16, 2020·BMC Evolutionary Biology·Elias DohmenCarsten Kemena
Aug 23, 2020·Animals : an Open Access Journal From MDPI·Lucy E Bearman-BrownRichard W Yarnell
Jul 10, 2021·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Gee-Way LinCheng-Ming Chuong

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Software Mentioned

ClustalW
BootScan
RDP2
BLAST
RDP
GeneConv
Mapviewer
MaxChi
BLASTn
PAML

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