Molecular evolution of the periphilin gene in relation to human endogenous retrovirus m element.

Journal of Molecular Evolution
Jae-Won HuhHeui-Soo Kim

Abstract

HERV-M (human endogenous retrovirus M), related to the super family of HERV-K, has a methionine (M) tRNA primer-binding site, and is located within the periphilin gene on human chromosome 12q12. HERV-M has been integrated into the periphilin gene as the truncated form, 5'LTR-gag-pol-3'LTR. Polymerase chain reaction (PCR) and reverse transcription-polymerase chain reaction (RT-PCR) approaches were conducted to investigate its evolutionary origins. Interestingly, the insertion of retroelements in a common ancestor genome can make different transcript variants in different species. In the case of the periphilin gene, human (10 variants) and mouse (2 variants) lineages show different transcript variants. Insertion of HERV-M (variant 1-3) could affect the protein-coding region. Also, Alusq/x (variant 4-9) and L1ME4a (mammalian-wide subfamilies of LINE-1) (variant 10) in humans and SINE (short interspersed repetitive element) and RLTR15 (the mouse putative long terminal repeat) (variant 2) in mice could be driving forces in transcript diversification of the periphilin gene during mammalian evolution. The HERV-M derived transcripts (variant 1-3) were expressed in different human tissues, whereas they were not detected in crab-eating m...Continue Reading

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Citations

Jun 2, 2011·Mobile DNA·Keith R Oliver, Wayne K Greene
May 18, 2007·Genes & Genetic Systems·Dae-Soo KimHeui-Soo Kim
Jan 5, 2012·Genes & Genetic Systems·Yun-Ji KimHeui-Soo Kim
Jan 29, 2016·Current Opinion in Genetics & Development·Antoine Molaro, Harmit S Malik
Oct 23, 2009·Annals of the New York Academy of Sciences·Luis P Villarreal
Oct 28, 2009·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Kung AhnHeui-Soo Kim
Jun 13, 2018·Nature Microbiology·Ghina ChouguiFlorence Margottin-Goguet
Feb 28, 2019·Frontiers in Microbiology·Ghina Chougui, Florence Margottin-Goguet
Sep 26, 2020·Nucleic Acids Research·Daniil M PrigozhinYorgo Modis

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