Molecular evolution of type II MAGE genes from ancestral MAGED2 gene and their phylogenetic resolution of basal mammalian clades

Mammalian Genome : Official Journal of the International Mammalian Genome Society
Marcos De DonatoIkhide G Imumorin

Abstract

Type II melanoma-associated antigens (MAGE) are a subgroup of about a dozen proteins found in various locations in the genome and expressed in normal tissues, thus are not related to cancer as the type I MAGE genes. This gene family exists as a single copy in non-mammals and monotremata, but found as two copies in metatherians and occur as a diverse group in all eutherians. Our studies suggest MAGED2 as the ancestor of this subfamily and the most likely evolutionary history of eutherian type II MAGE genes is hereby proposed based on synteny conservation, phylogenetic relations, genome location, homology conservation, and the protein and gene structures. Type II genes can be divided into two: those with 13 exons (MAGED1, MAGED2, TRO, and MAGED4) and those with only one exon (MAGEE1, MAGEE2, MAGEF1, NSMCE3, MAGEH1, MAGEL2, and NDN) with different evolutionary patterns. Our results suggest a need to change the gene nomenclature to MAGE1 (the ancestral gene), currently designated as LOC103095671 and LOC100935086, in opossum and Tasmanian devil, respectively, and MAGE2 (the duplicated one), currently designated as LOC100617402 and NDNL2, respectively, to avoid confusion. We reconstructed the phylogenetic relationships among 23 mamma...Continue Reading

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Citations

Apr 17, 2020·Learning & Memory·Michaelina N NarteyJohn H McLean
Dec 13, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Lara Valiño-RivasMaria Dolores Sanchez-Niño
Sep 15, 2020·The Journal of Biological Chemistry·Rebecca R Florke GeePatrick Ryan Potts
Aug 3, 2021·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Kazuaki Yoshikawa
Nov 5, 2021·Oncology Letters·Sanyan LiXianrong Zhou

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Methods Mentioned

BETA
ubiquitination

Software Mentioned

mVISTA
PhyML
LG4M
Mr
LG4X
ExPASy
Bayes
MapView
RepeatMasker
BLAST

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