Molecular evolution of vertebrate Toll-like receptors: evolutionary rate difference between their leucine-rich repeats and their TIR domains

Gene
Tomoko MikamiNorio Matsushima

Abstract

Toll-like receptors (TLRs) that initiate an innate immune response contain an extracellular leucine rich repeat (LRR) domain and an intracellular Toll IL-receptor (TIR) domain. There are fifteen different TLRs in vertebrates. The LRR domains, which adopt a solenoid structure, usually have higher rates of evolution than do the TIR globular domains. It is important to understand the molecular evolution and functional roles of TLRs from this standpoint. Both pairwise genetic distances and Ka/Ks's (the ratios between non synonymous and synonymous substitution rates) were compared between the LRR domain and the TIR domain of 366 vertebrate TLRs from 96 species (from fish to primates). In fourteen members (TLRs 1, 2, 3, 4, 5, 6, 7, 8, 9, 11/12, 13, 14, 21, and 22/23) the LRR domains evolved significantly more rapidly than did the corresponding TIR domains. The evolutionary rates of the LRR domains are significantly different among these members; LRR domains from TLR3 and TLR7 from primates to fishes have the lowest rate of evolution. In contrast, the fifteenth member, TLR10, shows no significant differences; its TIR domain is not highly conserved. The present results suggest that TLR10 may have a different function in signaling from ...Continue Reading

References

Jun 1, 1992·Computer Applications in the Biosciences : CABIOS·D T JonesJ M Thornton
Sep 1, 1997·Nucleic Acids Research·S F AltschulD J Lipman
Feb 10, 2000·Molecular Biology and Evolution·Z Yang, R Nielsen
Jul 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·S BauerG B Lipford
Aug 8, 2002·Journal of Molecular Evolution·Celeste J BrownA Keith Dunker
Oct 14, 2003·Trends in Immunology·Jessica K BellDavid M Segal
May 5, 2004·The Journal of Biological Chemistry·Javed A KhanLiang Tong
Dec 14, 2004·Nature·UNKNOWN International Chicken Genome Sequencing Consortium
Jun 18, 2005·Science·Jungwoo ChoeIan A Wilson
Jun 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jared C RoachAlan Aderem
Jul 27, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jessica K BellDavid R Davies
Jul 22, 2006·The Journal of Biological Chemistry·Rebecca J GibbardNicholas J Gay
Nov 10, 2006·The Journal of Biological Chemistry·Hidefumi ShinoharaYoshikatsu Matsubayashi
Feb 1, 2007·Immunogenetics·Akihiro IshiiTsukasa Seya
Aug 31, 2007·BMC Evolutionary Biology·Egbert K O KruithofRichard J Fish
Nov 6, 2007·Immunological Reviews·Arthur M Krieg, Jörg Vollmer
Jan 1, 2008·Fish & Shellfish Immunology·Johnny Shou-Chung ChenDaryi Wang
Jan 30, 2008·Nature Reviews. Genetics·François Leulier, Bruno Lemaitre
Apr 17, 2008·Immunogenetics·Austin L Hughes, Helen Piontkivska
Aug 15, 2008·Immunity·Mi Sun Jin, Jie-Oh Lee
Sep 24, 2008·Immunogenetics·Toshiaki NakajimaAkinori Kimura
Oct 22, 2008·BMC Evolutionary Biology·Oliver C JannElizabeth J Glass
Jan 31, 2009·Molecular Biology and Evolution·Gabriela WlasiukMichael W Nachman
Jun 10, 2009·Current Genomics·Hiroyuki OshiumiTsukasa Seya
Jun 13, 2009·Protein Science : a Publication of the Protein Society·Tiandi WeiShaila C Rössle
Jul 8, 2009·Biochimica Et Biophysica Acta·Norio MatsushimaYoshio Kuroki
Aug 19, 2009·Biochemical and Biophysical Research Communications·Himanshu KumarShizuo Akira
Oct 24, 2009·Veterinary Immunology and Immunopathology·Alexander ReblHans-Martin Seyfert
Jan 15, 2010·Protein Science : a Publication of the Protein Society·Andriy V KubarenkoAlexander N R Weber
Apr 23, 2010·Molecular Biology and Evolution·Gabriela Wlasiuk, Michael W Nachman
Jul 2, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Z L Chang
Jan 18, 2011·International Reviews of Immunology·Himanshu KumarShizuo Akira
Apr 13, 2011·Structure·Istvan BotosDavid R Davies

❮ Previous
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Citations

Sep 14, 2013·BMC Evolutionary Biology·Alena FornůskováJean-François Cosson
Aug 29, 2013·Developmental and Comparative Immunology·Danilo Pietretti, Geert F Wiegertjes
Feb 25, 2014·Developmental and Comparative Immunology·Zakia KanwalHerman P Spaink
Jun 7, 2014·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Srinivas Nellimarla, Karen L Mossman
Nov 13, 2014·Genetics, Selection, Evolution : GSE·Michal VinklerJosef Bryja
Oct 1, 2013·Journal of Molecular Biology·Christelle LangevinPierre Boudinot
Jan 8, 2013·Current Opinion in Immunology·Shen-Ying ZhangJean-Laurent Casanova
Oct 29, 2015·Molecular Ecology·Catalina Gonzalez-QuevedoDavid S Richardson
Aug 6, 2013·Immunology·Renzo Perales-Linares, Sonia Navas-Martin
Jul 22, 2014·Current Opinion in Microbiology·Samuel H Lewis, Darren J Obbard
Dec 7, 2014·Genome Biology and Evolution·Wiesław BabikPiotr Zieliński
Aug 10, 2016·Immunogenetics·Julia Schad, Christian C Voigt
Aug 16, 2016·Molecular Biology and Evolution·Joanne R ChapmanJonas Waldenström
Jan 8, 2016·Scientific Reports·Carlos G P VoogdtJos P M van Putten
Jan 1, 2012·Biomolecules·Norio Matsushima, Hiroki Miyashita
Dec 14, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicholas J HessRichard I Tapping
Dec 29, 2017·Medicinal Research Reviews·Mojtaba Khajeh Alizadeh AttarNima Rezaei
Jun 13, 2018·Molecular Biology and Evolution·Hana VelováMichal Vinkler
Jun 21, 2019·The Journal of Experimental Medicine·Hye Kyung LimShen-Ying Zhang
Mar 30, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Song JiangRichard I Tapping
Nov 28, 2012·Innate Immunity·Victoria Offord, Dirk Werling
Feb 26, 2020·Molecular Biology and Evolution·Hila LevyAdrian L Smith
Oct 14, 2020·Scandinavian Journal of Immunology·Si-Biao SuHai-Xing Jiang
Jan 11, 2021·Developmental and Comparative Immunology·Jiandong YangMing Zhang
Apr 3, 2021·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Ryan J DebuqueJames W Godwin
Nov 3, 2021·The Journal of Experimental Medicine·Jie ChenShen-Ying Zhang

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