Molecular features of the TSPY gene of gibbons and Old World monkeys

Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology
H S KimO Takenaka

Abstract

Restriction pattern, chromosome localization and the sequence of the testis-specific gene, TSPY, were investigated in the white-handed gibbon, agile gibbon, siamang, hamadryas baboon and Japanese monkey. Southern blot analysis showed the TSPY gene to be male specific in the primates used and disclosed variability of restriction pattern in gibbons. Fluorescence in situ hybridization demonstrated that the probe ppTSPY2372, biotinylated using polymerase chain reaction, is located as a slight signal in the proximal long arm of the Y chromosome of the white-handed gibbon, hamadryas baboon and Japanese monkey and in the middle long arm of the Y chromosome of the siamang, while a faint signal and an intense signal were detected in the proximal long arm of the Y chromosome of the aglle gibbon. These findings allow us to speculate that the gibbons might have evolved some structural differentiation in the TSPY gene. The first introns of the TSPY genes were sequenced and compared. One hundred thirty-seven of 606 sites were found to be variable, and 10 deletions/insertions were noted among these gibbons, two species of Old World monkeys and human. Sequence similarity ranged from 81.7% between humans and hamadryas baboons to 98.7% between J...Continue Reading

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Citations

May 14, 2003·Molecular Phylogenetics and Evolution·Anthony J TosiDon J Melnick
May 26, 2001·AIDS Research and Human Retroviruses·H S Kim, W H Lee
Mar 10, 2001·AIDS Research and Human Retroviruses·J Y ChoiH S Kim
Jan 10, 2002·AIDS Research and Human Retroviruses·H S Kim
Mar 3, 1999·AIDS Research and Human Retroviruses·H S Kim, T J Crow
Aug 23, 2012·BMC Evolutionary Biology·Yi-Chiao ChanLinda Vigilant
Feb 28, 2006·Genes & Genetic Systems·Eun-Sil ParkHeui-Soo Kim
Aug 5, 2003·Evolution; International Journal of Organic Evolution·Anthony J TosiDon J Melnick
May 30, 2003·Biology of Reproduction·S SchubertJ Schmidtke
Sep 8, 2007·Archives of Virology·J-W HuhH-S Kim
Dec 31, 2005·Archives of Virology·J-M Yi, H-S Kim
Mar 20, 2010·Biology of Reproduction·Anja SchönerStephanie Schubert
Aug 9, 2013·American Journal of Alzheimer's Disease and Other Dementias·Kazuki UchimotoHitoshi Okamura
Mar 23, 1999·Genes & Genetic Systems·H S Kim
Mar 10, 2004·Journal of Human Genetics·Joo-Mi Yi, Heui-Soo Kim
Feb 17, 2021·BMC Ecology and Evolution·Jeffrine J Rovie-RyanMohd Tajuddin Abdullah
Nov 21, 2000·Molecular Phylogenetics and Evolution·A J TosiD J Melnick
Sep 26, 2006·Biochemical and Biophysical Research Communications·Tatsuo Kido, Yun-Fai Chris Lau
May 14, 2008·Placenta·J-W HuhH-S Kim

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