Molecular forms of plasma and urinary adrenomedullin in normal, essential hypertension and chronic renal failure

Journal of Hypertension
T NishikimiK Kangawa

Abstract

Human adrenomedullin precursor is converted to glycine-extended adrenomedullin (AM-Gly), an intermediate inactive form of adrenomedullin. Subsequently, AM-Gly is converted to active form of mature adrenomedullin (AM-m). The aim of the present study was to investigate (i) whether sex or age influences plasma and urinary AM-m and AM-Gly levels in normal subjects; (ii) the daytime variability of plasma AM-m and AM-Gly levels in normal subjects; (iii) AM-m and AM-Gly levels and its ratio in plasma and urine in normal subjects, individuals with essential hypertension (HT), and chronic renal failure (CRF); and (iv) the ratio of AM-m and AM-total (T) in plasma of various veins and aorta. We measured plasma levels and urinary excretions of AM-m, AM-Gly and AM-T (AM-m + AM-Gly) by recently developed immunoradiometric assay in normal subjects (n = 81), HT (n = 28) and CRF (n = 30). We also determined the molecular forms of plasma adrenomedullin taken from various sites during angiography in patients with suspected renovascular hypertension (n = 9). There were no differences in plasma and urinary excretions of two molecular forms of adrenomedullin among sexes or ages in normal subjects. There was no daytime variation of plasma two molecul...Continue Reading

References

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Citations

May 20, 2005·The Journal of Laboratory and Clinical Medicine·Mei-Chuan KuoHung-Chun Chen
Aug 31, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Shufeng ChenJianfeng Huang
Sep 30, 2005·Seminars in Dialysis·Mathavakkannan Suresh, Ken Farrington
Feb 24, 2006·Journal of Sleep Research·Richard SchulzFrank Rose
Sep 6, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Johji KatoTanenao Eto
Aug 8, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Chikako Iemura-InabaHiroaki Matsuoka
May 4, 2011·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Ariadne AvellinoGregory J Fermann
Jan 11, 2018·Expert Review of Molecular Diagnostics·Justin J Choi, Matthew W McCarthy
Oct 1, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kakon NagShigehisa Hirose

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