Molecular functions and specific roles of circRNAs in the cardiovascular system

Non-coding RNA Research
Lesca M HoldtDaniel Teupser

Abstract

As part of the superfamily of long noncoding RNAs, circular RNAs (circRNAs) are emerging as a new type of regulatory molecules that partake in gene expression control. Here, we review the current knowledge about circRNAs in cardiovascular disease. CircRNAs are not only associated with different types of cardiovascular disease, but they have also been identified as intracellular effector molecules for pathophysiological changes in cardiovascular tissues, and as cardiovascular biomarkers. This evidence is put in the context of the current understanding of general circRNA biogenesis and of known interactions of circRNAs with DNA, RNA, and proteins.

Citations

Jan 30, 2019·International Journal of Molecular Sciences·Lina BadimonGemma Vilahur
Oct 28, 2019·Chinese Medical Journal·Dong LiXiao-Hua Zhu
Jun 13, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Nana MaJun Wan
Sep 17, 2019·International Journal of Molecular Medicine·Yanhong YangJiao Guo
Mar 13, 2020·Journal of Cardiovascular Translational Research·Bo ZhaoSheng Zhao
Aug 20, 2020·Circulation. Genomic and Precision Medicine·Saumya DasUNKNOWN American Heart Association Council on Genomic and Precision Medicine; Council on Arteriosclerosis, Thrombosis and Vascular B
Sep 27, 2018·International Journal of Molecular Sciences·Xuanping ZhangJiayin Wang
May 18, 2019·Journal of Neurochemistry·Shanshan LuJie Yan
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Feb 10, 2021·Journal of Cellular Physiology·Chenlong LiPeng Liang

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Methods Mentioned

BETA
RNAseq
deamination
pulldown
RNA-seq
co-immunoprecipitation
footprinting
circRNA knockout
transgenic
transgenics
antisense oligonucleotides

Software Mentioned

CIRI
PTESFinder
KNIFE
finder
DCC
ANRIL
circRNA
circ
RNAseq
NCLScan

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