PMID: 11921286Mar 29, 2002Paper

Molecular genetic analysis of chromosome 9 candidate tumor-suppressor loci in bladder cancer cell lines

Genes, Chromosomes & Cancer
Sarah V WilliamsMargaret A Knowles

Abstract

Underrepresentation of chromosome 9 is a common finding in bladder cancer. Frequent loss of the whole chromosome suggests the presence of at least one relevant tumor suppressor gene on each arm. Candidate regions identified by loss of heterozygosity (LOH) analysis include a region at 9p21 containing CDKN2A, which encodes p16 and p14(ARF), a large region at 9q12-31 including PTCH and many other genes, a small region at 9q32-33, which includes the DBCCR1 gene, and a region at 9q34 including the TSC1 gene. Experimental replacement of genes or chromosomes into tumor cells with appropriate deletions or mutations represents an important approach to test the functional significance of candidate tumor suppressor genes. Loss of an entire copy of chromosome 9 in many bladder tumor cell lines provides no indication of which gene or genes are affected, and selection of appropriate recipient cells for gene replacement is difficult. We have investigated three candidate tumor suppressor genes on chromosome 9 (CDKN2A, DBCCR1, and TSC1), at the DNA level and by expression analysis in a panel of bladder tumor cell lines, many of which have probable LOH along the length of the chromosome, as indicated by homozygosity for multiple polymorphic mark...Continue Reading

References

Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·H M AlbertsenD Cohen
Oct 1, 1986·The Journal of Urology·H B GrossmanB Cox
May 1, 1973·International Journal of Cancer. Journal International Du Cancer·J BubeníkJ Donner
Oct 1, 1995·Nature Genetics·P CairnsD Sidransky
Oct 18, 1995·Journal of the National Cancer Institute·I OrlowC Cordon-Cardo
Apr 21, 1995·International Journal of Cancer. Journal International Du Cancer·G SauterF M Waldman
Sep 1, 1993·Human Molecular Genetics·A J LinnenbachS B Malkowicz
Sep 1, 1995·Human Molecular Genetics·M P WilliamsonM A Knowles
Sep 17, 1998·Japanese Journal of Cancer Research : Gann·M OyaW A Schulz
Jun 3, 1999·Oncogene·N HornigoldM A Knowles
Nov 13, 1999·Nature Cell Biology·J D WeberD Bar-Sagi
Sep 19, 2000·Genes, Chromosomes & Cancer·I Fadl-ElmulaS Heim
May 1, 2001·The Journal of Pathology·A A van TilborgE C Zwarthoff
Jul 14, 2001·Journal of Human Genetics·H FujiwaraT Habuchi

❮ Previous
Next ❯

Citations

Apr 19, 2007·World Journal of Urology·Hans-Helge SeifertWolfgang A Schulz
Dec 7, 2006·Nature Clinical Practice. Urology·Kokichi Sugano, Tadao Kakizoe
Jul 13, 2005·DNA and Cell Biology·Hideshi IshiiAndrea Vecchione
Aug 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·M Anaul KabirElena Rustchenko
Jan 29, 2014·Proceedings of the National Academy of Sciences of the United States of America·Carl D MorrisonDonald L Trump
Nov 3, 2004·Journal of Cellular Physiology·Ingo ThievessenWolfgang A Schulz
Apr 23, 2005·Genes, Chromosomes & Cancer·Sarah V WilliamsMargaret A Knowles
Aug 3, 2006·International Journal of Urology : Official Journal of the Japanese Urological Association·Norio NonomuraAkihiko Okuyama
Feb 14, 2006·Cancer·Paulette Mhawech-FaucegliaJuerg Schwaller
Mar 24, 2016·Cancer Biomarkers : Section a of Disease Markers·Ahmed MahasMichael Markey
Mar 17, 2011·PloS One·Vera N SenchenkoMichael I Lerman
Nov 15, 2007·Cytogenetic and Genome Research·K NevelingD Schindler
Dec 20, 2007·Current Opinion in Urology·Shahrokh F ShariatSeth P Lerner
Jun 1, 2010·Journal of Cellular Biochemistry·Min YangXinyuan Liu
Nov 13, 2003·Médecine sciences : M/S·Hélène LaRueYves Fradet
May 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hiroaki KawanishiOsamu Ogawa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.