PMID: 9174138May 1, 1997Paper

Molecular genetic analysis of HLA class II alleles in Japanese patients with melanoma

Tissue Antigens
T KageshitaH Inoko

Abstract

Distribution of HLA-DQA, -DQB and -DPB alleles in ninety-six Japanese patients with melanoma was analyzed using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method, and the association between clinical parameters and the presence of certain HLA class II alleles investigated. The frequency of HLA-DQB1*0302 was increased, while those of DQA1*0101(04), -DQA1*0401 and DRB1*0802 were decreased in melanoma patients compared with controls. Moreover, the frequency of HLA-DQA1*0103 in patients with acral lentiginous melanoma was increased compared with controls. However, none of these HLA class II alleles showed significant positive or negative associations after correction of the P value. In addition, there was no correlation between these antigens and clinical parameters. These results indicate that HLA class II alleles may not contribute to a strong susceptibility to melanoma in the Japanese.

References

Sep 1, 1979·Journal of the National Cancer Institute·M L Kripke
Aug 1, 1991·Tissue Antigens·M OtaH Inoko
Sep 19, 1991·The New England Journal of Medicine·J W Streilein
Dec 15, 1984·International Journal of Cancer. Journal International Du Cancer·G Mueller-EckhardtC Mueller-Eckhardt
Nov 15, 1994·International Journal of Cancer. Journal International Du Cancer·J E LeeC D Platsoucas
Nov 1, 1995·Journal of Immunotherapy with Emphasis on Tumor Immunology : Official Journal of the Society for Biological Therapy·F M MarincolaD R Parkinson

❮ Previous
Next ❯

Citations

Jul 27, 1999·The Journal of Pathology·A C Bateman, W M Howell
Jul 13, 2004·Cancer Immunology, Immunotherapy : CII·Elissaveta NaumovaMiglena Toneva
Mar 21, 2006·Cancer Immunology, Immunotherapy : CII·Elissaveta NaumovaSnejina Mihailova
Dec 4, 2002·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Jennifer R StalkupRajani Katta
May 16, 2012·Journal of the American Academy of Dermatology·Katherine A WardMaria K Hordinsky
Apr 7, 2012·Anais Brasileiros De Dermatologia·Renan Rangel BonamigoAngela Caroline de Zorzi Pinto

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.