PMID: 24364142Dec 25, 2013Paper

Molecular genetic analysis of the isoniazid-resistant strains of M. tuberculosis circulating over the Saratov region

Molekuliarnaia genetika, mikrobiologiia i virusologiia
T Iu Salina, T I Morozova

Abstract

257 patients with active lung tuberculosis in the Saratov region were tested for distribution and mutation spectrum of the genes katG, inhA, ahpC encoding Isoniazid-resistance. The tests were implemented using the biological microchips with pharmacological kits TV-Biochip MDR (Russia). The rate of the Isoniazid-resistant M. tuberculosis strains incidence was found to be 55.7%. The Isoniazid-resistant strains demonstrated high rate (26.9%) of combined mutations in 2 and 3 genes simultaneously, domination in the katG ser315 -> Thrl (91.1%), thereby inducing high resistance to Isoniazid. The sensitivity of the TV-Biochip MDR test-system was 88.2%; the specificity, 91.3%. The results ofthis work show that the incidence of the Isoniazid-resistant strains should be limited using additional measures.

Citations

May 14, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·H EsmailR J Wilkinson
Sep 20, 2015·Journal of Medical Microbiology·Anne-Laure BanulsSylvain Godreuil

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antitubercular Agents (ASM)

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antitubercular Agents

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Related Papers

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
X WuZ Hu
The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
P DobnerH Rinder
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
Xi ChenQing Wang
© 2021 Meta ULC. All rights reserved