Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus.

Proceedings of the National Academy of Sciences of the United States of America
Stephen B BeresJames M Musser

Abstract

In recent years we have studied the relationship between strain genotypes and patient phenotypes in group A Streptococcus (GAS), a model human bacterial pathogen that causes extensive morbidity and mortality worldwide. We have concentrated our efforts on serotype M3 organisms because these strains are common causes of pharyngeal and invasive infections, produce unusually severe invasive infections, and can exhibit epidemic behavior. Our studies have been hindered by the lack of genome-scale phylogenies of multiple GAS strains and whole-genome sequences of multiple serotype M3 strains recovered from individuals with defined clinical phenotypes. To remove some of these impediments, we sequenced to closure the genome of four additional GAS strains and conducted comparative genomic resequencing of 12 contemporary serotype M3 strains representing distinct genotypes and phenotypes. Serotype M3 strains are a single phylogenetic lineage. Strains from asymptomatic throat carriers were significantly less virulent for mice than sterile-site isolates and evolved to a less virulent phenotype by multiple genetic pathways. Strain persistence or extinction between epidemics was strongly associated with presence or absence, respectively, of the...Continue Reading

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Citations

Oct 7, 2009·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·R MeisalJ M Musser
Dec 20, 2012·Nature Communications·Christofer KarlssonJohan Malmström
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Mar 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Min LiMichael Otto
Feb 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Stephen B BeresJames M Musser
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Randall J OlsenJames M Musser
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Sep 5, 2009·The Journal of Clinical Investigation·James M Musser, Samuel A Shelburne

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