Molecular genetic basis of porcine histo-blood group AO system.

Blood
Fumiichiro Yamamoto, M Yamamoto

Abstract

Histo-blood group A and B antigens are oligosaccharide antigens important in transfusion and transplantation medicine. The final steps in the synthesis of these antigens are catalyzed by glycosyltransferases encoded by the functional alleles at the ABO locus. Humans have 3 major alleles (A, B, and O), whereas pigs are known to have only A and O alleles. This paper reports the molecular genetic basis of the porcine AO system. The porcine A gene is homologous to the ABO genes in humans and other species. It encodes an alpha1 --> 3 N-acetyl-D-galactosaminyltransferase that synthesizes A antigens. Southern hybridization experiments using a porcine A gene coding-sequence probe failed to identify a corresponding homologous sequence in genomic DNA from group O pigs, thus suggesting a major deletion in the O gene. Therefore, inadvertent activation of a silent O gene seems unlikely in porcine organs xenotransplanted into humans.

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Citations

Mar 16, 2002·Transfusion·Francis RoubinetAntoine Blancher
Jul 19, 2013·Transplantation·Mylvaganam JeyakanthanLori J West
Sep 29, 2011·Transfusion Medicine Reviews·Fumiichiro YamamotoAntoine Blancher
Jun 2, 2010·Clinics in Laboratory Medicine·David K C CooperMark Yazer
Jun 24, 2009·Transplantation Proceedings·S-C YeomW-J Lee
Oct 14, 2014·Scientific Reports·Fumiichiro YamamotoAntoine Blancher
May 11, 2007·Xenotransplantation·Françoise A RouxJack-Yves Deschamps
Jun 8, 2006·Xenotransplantation·Douglas M SmithLesley Kresie
May 11, 2007·Xenotransplantation·Françoise A RouxJack-Yves Deschamps
Jan 14, 2011·Journal of Forensic Sciences·Ken WatanabeKoichi Sakurada
Mar 13, 2013·Legal Medicine·Ken WatanabeKoichi Sakurada
Mar 25, 2017·Viruses·Anastasia N VlasovaLinda J Saif
Apr 1, 2018·Xenotransplantation·Guerard ByrneChristopher McGregor
Jul 12, 2007·Expert Reviews in Molecular Medicine·Ming Tan, Xi Jiang
Jul 24, 2020·Journal of the American Heart Association·Olivier SchusslerAlain Carpentier
Mar 1, 2020·Communications Biology·Tanya R McKitrickRichard D Cummings

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