Molecular genetic basis of ribotyping.

Clinical Microbiology Reviews
Valérie BouchetRichard Goldstein

Abstract

Nearly 2,000 ribotyping-based studies exist, ranging from epidemiology to phylogeny and taxonomy. None precisely reveals the molecular genetic basis, with many incorrectly attributing detected polymorphisms to rRNA gene sequences. Based on in silico genomics, we demonstrate that ribotype polymorphisms result from sequence variability in neutral housekeeping genes flanking rRNA operons, with rRNA gene sequences serving solely as conserved, flank-linked tags. We also reveal that from such an informatics perspective, it is readily feasible a priori to design an interpretable ribotyping scheme for a genomically sequenced microbial species, and we discuss limitations to the basic restriction fragment length polymorphism-based method as well as alternate PCR ribotyping-based schemes.

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Citations

Jul 6, 2013·Systematic and Applied Microbiology·Peter Schumann, Rüdiger Pukall
Aug 22, 2009·Foodborne Pathogens and Disease·Marin Pavlic, Mansel W Griffiths
Oct 23, 2013·The Journal of Infectious Diseases·Rituparna DeG Balakrish Nair
Apr 9, 2013·International Journal of Food Microbiology·Lisa BarcoAntonia Ricci
Oct 27, 2015·Frontiers in Microbiology·Md Habibur RahamanMunirul Alam
May 15, 2012·Journal of Basic Microbiology·Francesca BorgoMaria Grazia Fortina
Mar 18, 2016·Nucleic Acids Research·Yanming ZhangFangqing Zhao
Nov 14, 2015·Critical Reviews in Food Science and Nutrition·Yao Mianzhi, Nagendra P Shah
Mar 13, 2010·Microbiological Research·J Rajendhran, P Gunasekaran
Nov 16, 2013·Critical Reviews in Microbiology·Chunlei ShiAndrea Isabel Moreno Switt
Jul 13, 2014·Diabetes Research and Clinical Practice·Hui-Qi Qu, Zhi-Dong Jiang
Dec 19, 2013·Critical Reviews in Food Science and Nutrition·Ling-Lin Fu, Jian-Rong Li
May 16, 2019·Microorganisms·Ricardo Franco-DuarteCélia F Rodrigues
Dec 12, 2018·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Orville St E RoachfordBidyut R Mohapatra
Dec 19, 2017·The Science of the Total Environment·Ying-Ning HoChien-Shun Chiou

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