Abstract
Data from epidemiological studies have demonstrated that genetics is an important risk factor for psychosis. The present study is part of a larger project, pioneer in Brazil, which has been conducted by other researchers who intend to follow a high-risk population (children) for the development of schizophrenia and bipolar disorder. In this first phase of the project, the objective was to investigate the distribution of four candidate genetic polymorphisms for functional psychosis (Ser9Gly DRD3, 5HTTLPR, the VNTR 3'-UTR SLC6A3 and Val66Met BDNF) in a case-control sample. A total of 105 women (58 with schizophrenia and 47 with bipolar disorder) and 62 gender-matched controls were investigated. Allele and genotype distributions of all identified functional polymorphisms did not differ statistically between cases and controls. These results suggest that the investigated polymorphisms were not related to susceptibility to functional psychoses in our Brazilian sample. These findings need to be validated in larger and independent studies.
References
Dec 1, 1992·Genomics·D J VandenberghG R Uhl
Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Jun 1, 1996·Journal of Neurochemistry·A HeilsK P Lesch
Feb 13, 1999·The Journal of Heredity·J Ott
Oct 6, 2000·Biological Psychiatry·W H Berrettini
Apr 24, 2001·Molecular Psychiatry·P SemwalB K Thelma
May 30, 2001·American Journal of Medical Genetics·G ElvidgeN Craddock
Oct 12, 2001·Schizophrenia Research·A LaaksoJ Hietala
Mar 23, 2002·The Pharmacogenomics Journal·S T WeissL J Palmer
Jan 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·Flavia C ParraSérgio D J Pena
Feb 3, 2004·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Ayman H FanousK S Kendler
Apr 20, 2004·Psychiatric Genetics·Erik G JönssonMarc-Antoine Crocq
Nov 30, 2004·Schizophrenia Research·F GammaMing T Tsuang
Apr 13, 2005·Molecular Psychiatry·H J ChoD A Collier
Jul 5, 2005·European Archives of Psychiatry and Clinical Neuroscience·Wolfgang MaierMarcella Rietschel
Dec 2, 2005·Schizophrenia Bulletin·Nick CraddockMichael J Owen
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Camila GuindaliniGerome Breen
Apr 11, 2006·Harvard Review of Psychiatry·James B Potash
Apr 28, 2006·American Journal of Human Genetics·Xian-Zhang HuDavid Goldman
Jun 20, 2006·European Archives of Psychiatry and Clinical Neuroscience·Gerald StöberMichael Knapp
Feb 10, 2007·Schizophrenia Research·Ming-Qing XuLin He
Apr 10, 2007·Psychiatric Genetics·Tetsufumi KanazawaMing T Tsuang
Jul 2, 2008·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Elisa Kijner GuttFrancisco Lotufo-Neto