Molecular genetic characteristics of influenza A virus clinically isolated during 2011-2016 influenza seasons in Korea

Influenza and Other Respiratory Viruses
Han Sol LeeWoo Joo Kim

Abstract

The influenza virus is reportedly associated with 3-5 million cases of severe illness and 250 000-500 000 deaths annually worldwide. We investigated the variation of influenza A virus in Korea and examined the association with death. A total of 13 620 cases were enrolled in the Hospital-based Influenza Morbidity & Mortality surveillance system in Korea during 2011-2016. Among these cases, a total of 4725 were diagnosed with influenza using RT-PCR (influenza A; n = 3696, influenza B; n = 928, co-infection; n = 101). We used 254 viral sequences from the 3696 influenza A cases for phylogenetic analysis using the BioEdit and MEGA 6.06 programs. We found that the sequences of A/H3N2 in the 2011-2012 season belong to subgroup 3C.1, whereas the sequences in the 2012-2013 season pertain to subgroup 3C.2. The sequences in the 2013-2014 and 2014-2015 seasons involve subgroups 3C.3a and 3C.2a. The A/H1N1pdm09 subtype belongs to subgroup 6 and contains two clusters. In addition, sequence analysis confirmed the several substitutions of internal genes and gene substitutions associated with drug resistance (I222V in NA and S31N in M2) in the fatal cases. While statistical analysis found no significant associations between genetic differences ...Continue Reading

References

Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·E D KilbourneB Grajower
Jun 26, 2004·Science·Derek J SmithRon A M Fouchier
Nov 17, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mariana BazGuy Boivin
Jan 6, 2009·Proceedings of the National Academy of Sciences of the United States of America·Angela WahlWilliam H Hildebrand
Aug 5, 2009·Antimicrobial Agents and Chemotherapy·Aeron C HurtIan G Barr
Aug 24, 2012·PloS One·Uzma Bashir AamirAlexander Klimov
Jan 11, 2013·Proceedings of the National Academy of Sciences of the United States of America·Jun WangWilliam F Degrado
Apr 4, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Tommy Tsan-Yuk LamFrederick Chi-Ching Leung
May 21, 2013·Current Protocols in Microbiology·Amanda L BalishAlexander I Klimov
Jun 28, 2013·Science Translational Medicine·Sourya ShresthaPejman Rohani
Sep 27, 2013·Influenza and Other Respiratory Viruses·Carol JosephNahoko Shindo
Oct 11, 2014·Expert Review of Anti-infective Therapy·Nick SpanakisAthanassios Tsakris
Dec 3, 2014·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Tie-Juan ShaoXin Qian

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Methods Mentioned

BETA
PCR
glycosylation

Software Mentioned

Graphpad ® Prism
MEGA

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