Molecular Genetic Contributions to Social Deprivation and Household Income in UK Biobank

Current Biology : CB
W David HillIan J Deary

Abstract

Individuals with lower socio-economic status (SES) are at increased risk of physical and mental illnesses and tend to die at an earlier age [1-3]. Explanations for the association between SES and health typically focus on factors that are environmental in origin [4]. However, common SNPs have been found collectively to explain around 18% of the phenotypic variance of an area-based social deprivation measure of SES [5]. Molecular genetic studies have also shown that common physical and psychiatric diseases are partly heritable [6]. It is possible that phenotypic associations between SES and health arise partly due to a shared genetic etiology. We conducted a genome-wide association study (GWAS) on social deprivation and on household income using 112,151 participants of UK Biobank. We find that common SNPs explain 21% of the variation in social deprivation and 11% of household income. Two independent loci attained genome-wide significance for household income, with the most significant SNP in each of these loci being rs187848990 on chromosome 2 and rs8100891 on chromosome 19. Genes in the regions of these SNPs have been associated with intellectual disabilities, schizophrenia, and synaptic plasticity. Extensive genetic correlatio...Continue Reading

References

Sep 29, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·George L WehbyFredric D Wolinsky
Mar 25, 2018·Genes, Brain, and Behavior·Abdel AbdellaouiJ T Cacioppo
Dec 24, 2017·Scientific Reports·Péter P UjmaMartin Dresler
Dec 1, 2018·Psychological Science·Gideon NavePhilipp D Koellinger
Jan 18, 2018·Nature Reviews. Genetics·Robert Plomin, S von Stumm
Aug 19, 2020·Annals of Clinical and Translational Neurology·Linjing ZhangDongsheng Fan
Feb 23, 2017·Journal of Alzheimer's Disease : JAD·Riccardo E MarioniIan J Deary
Dec 24, 2018·American Journal of Physical Anthropology·Indrikis KramsMarkus J Rantala
May 13, 2020·Molecular Psychiatry·S Fleur W MeddensPhilipp D Koellinger
Aug 11, 2020·Schizophrenia Research and Treatment·Jingchun ChenXiangning Chen
Oct 29, 2017·Proceedings of the National Academy of Sciences of the United States of America·Eva KrapohlRobert Plomin
Jan 12, 2019·NPJ Science of Learning·H Moriah Sokolowski, Daniel Ansari
Apr 12, 2019·Molecular Psychiatry·A G AllegriniRobert Plomin
Apr 10, 2019·Nature Human Behaviour·Daniel W BelskyCandice L Odgers
May 13, 2020·Nature Human Behaviour·K Paige Harden, Philipp D Koellinger
Jun 9, 2018·Nature Human Behaviour·Kaili RimfeldRobert Plomin
Sep 28, 2019·Perspectives on Psychological Science : a Journal of the Association for Psychological Science·Reut Avinun
Oct 23, 2019·Nature Human Behaviour·Abdel AbdellaouiPeter M Visscher
Jan 19, 2018·The Behavioral and Brain Sciences·James M Sherlock, Brendan P Zietsch

Citations

Dec 3, 1994·BMJ : British Medical Journal·K MacRae
Sep 23, 2003·Health & Social Care in the Community·Alison Bowes, Heather Wilkinson
Dec 21, 2010·American Journal of Human Genetics·Jian YangPeter M Visscher
Jun 12, 2013·Nature Reviews. Genetics·Nadia SolovieffJordan W Smoller
Jan 15, 2014·Autoimmunity Reviews·Omar-Javier Calixto, Juan-Manuel Anaya
Jun 20, 2014·Intelligence·Riccardo E MarioniIan J Deary
Mar 18, 2015·Molecular Psychiatry·G JunL A Farrer
May 20, 2015·Nature Genetics·Tinca J C PoldermanDanielle Posthuma
Sep 29, 2015·Nature Genetics·Brendan Bulik-SullivanBenjamin M Neale

Related Concepts

Genome-Wide Association Study
Genome
Genes
Schizophrenia
Brain
Ability to Perform Cognitive Activity
Fetishism (Psychiatric)
Entire Central Nervous System
Etiology
Neuronal Plasticity

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

© 2020 Meta ULC. All rights reserved