Molecular genetic differentiation between primary lung cancers and lung metastases of other tumors

The Journal of Thoracic and Cardiovascular Surgery
D KandiolerE Wolner

Abstract

When solitary pulmonary tumors are observed in patients with a history of cancer, differentiation between metastasis and primary lung cancer is crucial for appropriate therapy. Assuming that p53 mutations are conserved in metastases, mutation analysis of the p53 gene would be a valuable tool in differentiating metastases from primary carcinomas of the lung. In nine of 267 resected lung tumors, the origin of the lung tumor could not be defined histologically. Five patients had a history of colorectal carcinoma, one had a history of breast carcinoma, one had a history of soft-tissue carcinoma, and one had a history of head and neck carcinoma. One patient with a clear cell carcinoma of the lung had been surgically treated for both renal and thyroid cancer. Material from one patient with adenocarcinoma of the lung, histologically defined regional lymph nodes, and distant brain metastasis served as a control. We extracted deoxyribonucleic acid from the snap-frozen tissue of the unclassified lung tumors, from paraffin-embedded tissue of the previously removed primary cancers, and also from peripheral blood of the patients. Exons 2 to 11 of the p53 gene were amplified in separated polymerase chain reactions and directly sequenced. In ...Continue Reading

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Citations

Jan 30, 2002·Cancer·Marcel Th M van RensPieter J Slootweg
Aug 28, 2002·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Masaki TomitaToshio Onitsuka
Nov 27, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·J P van Meerbeeck
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Aug 17, 2018·Annals of the New York Academy of Sciences·Tamara BraunschmidDaniela Kandioler

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