PMID: 9176883May 1, 1997Paper

Molecular genetic events in the development and progression of ovarian cancer in humans

Molecular Medicine Today
R F ChuaquiM J Merino

Abstract

Ovarian tumor development is characterized by specific clinical and pathological features that provide an interesting model of carcinogenesis: first, the pre-invasive and even invasive lesions are difficult to detect; second, a group of cases with a known familial predilection constitute an important heredltary model of carcinogenesis; and third, the category of morphologically borderline ovarian tumors (tumors of low malignant potential) poses several unanswered questions such as: what histologic criteria should be used for their diagnosis; what is their natural history; and what is their molecular relationship to invasive tumors? Recently, molecular studies have contributed to a better understanding of the biology of these tumors, their behavior in vivo, and their response to therapy. This article summarizes the most recent molecular advances.

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Citations

Feb 25, 2000·Cancer Genetics and Cytogenetics·H TworekR A DiCioccio
Apr 25, 2003·International Journal of Cancer. Journal International Du Cancer·Nicola A ThomasIan G Campbell
Dec 18, 2001·The Oncologist·D S Goodsell
Mar 12, 2002·British Journal of Haematology·John T Reilly
Feb 13, 2003·British Journal of Haematology·Faisel M Abu-DuhierJohn T Reilly
Nov 18, 2003·British Journal of Haematology·Faisel M Abu-DuhierJohn T Reilly

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