Molecular genetic pathways in Parkinson's disease: a review

Clinical Science
Shushant JainDaniel G Healy

Abstract

Major progress has been made in the last decade in understanding the genetic basis of PD (Parkinson's disease) with five genes unequivocally associated with disease. As a result, multiple pathways have been implicated in the pathogenesis of PD, including proteasome impairment and mitochondrial dysfunction. Although Mendelian genetics has been successful in establishing a genetic predisposition for familial PD, this has not been reiterated in the sporadic form. In fact no genetic factors have been unequivocally associated with increased risk for sporadic PD. The difficulty in identifying susceptibility factors in PD has not only been because of numerous underpowered studies, but we have been unable to dissect out the genetic component in a multifactorial disease. This review aims to summarize the genetic findings within PD.

References

Jun 3, 1989·Lancet·A H SchapiraC D Marsden
Aug 28, 1997·Nature·Maria Grazia SpillantiniM Goedert
Mar 21, 1998·Nature Genetics·Thomas GasserR D Horstmann
Jun 18, 1998·Annals of Neurology·M MuenterDonald B Calne
Oct 17, 1998·Nature·E LeroyM H Polymeropoulos
Feb 3, 1999·JAMA : the Journal of the American Medical Association·C TannerJ W Langston
Jul 9, 1999·American Journal of Hematology·M MachaczkaW Jurczak
Dec 15, 2000·The New England Journal of Medicine·S SveinbjörnsdottirKári Stefánsson
Feb 24, 2001·Annals of the New York Academy of Sciences·M Hutton
Sep 5, 2001·Human Molecular Genetics·Matthew FarrerD Hernandez
Sep 18, 2001·Annals of Neurology·Matthew FarrerJ W Langston
Sep 21, 2001·American Journal of Human Genetics·J AltmüllerM Wjst
Sep 26, 2001·European Journal of Human Genetics : EJHG·A B WestThomas Gasser
Nov 15, 2001·The Journal of Biological Chemistry·Amy B Manning-BogDonato A Di Monte
Nov 17, 2001·JAMA : the Journal of the American Medical Association·William K ScottMargaret A Pericak-Vance
Mar 5, 2002·American Journal of Human Genetics·Yi-Ju LiMargaret A Pericak-Vance
Mar 29, 2002·American Journal of Human Genetics·Anita L DeStefanoRichard H Myers
Jun 12, 2002·American Journal of Human Genetics·Nathan PankratzParkinson Study Group
Jun 29, 2002·Reviews on Environmental Health·David G Le CouteurAllan J McLean
Aug 20, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·I MizutaS Kuno
Sep 5, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Jian WangLong Yu
Oct 29, 2002·Annals of Neurology·Andrew A HicksSigurlaug Sveinbjörnsdóttir

Citations

Sep 17, 2013·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Brett Langley, Anthony Sauve
Mar 29, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M C ShihR A Bressan
Aug 28, 2015·Human Molecular Genetics·Zhi Dong ZhouEng-King Tan
Sep 20, 2012·Biochemical Society Transactions·Elisa BelluzziGiovanni Piccoli
Aug 5, 2008·Neurobiology of Disease·Anthony K F LiouMichael J Zigmond
Aug 9, 2007·Annals of Neurology·An GorisStephen J Sawcer
Nov 13, 2007·Journal of Neurochemistry·Robert E Burke
Aug 26, 2011·Biomedit︠s︡inskai︠a︡ khimii︠a︡·O A Buneeva, A E Medvedev
Nov 7, 2018·Molecular Neurobiology·Khosro JamebozorgiAmirhossein Sahebkar

Related Concepts

Related Feeds

Alpha-Synuclein Aggregation (MDS)

Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.

© 2021 Meta ULC. All rights reserved