Molecular genetic testing in the United States: comparison with international practice

Genetic Testing
Margaret M McGovernIra M Lubin

Abstract

To compare data on the practices of molecular genetic testing (MGT) in laboratories in the United States with those in 18 other countries. A Web-based survey of MGT laboratory directors (n = 827; response rate 63%) in 18 countries on three continents was carried out, and the response from U.S. laboratories compared to all others. Quality assurance and reporting indices were developed and calculated for each responding laboratory. A comparison of U.S. results with all other countries identified differences in laboratory setting, personnel qualifications, and the specific tests being offered, but similar rates of adherence to MGT quality standards and reporting practices were found. The survey also documented substantial transborder flow of specimens, most commonly due to the lack of availability of the test in the United States or because the test was available only through a research protocol, highlighting the need for common reporting and practice guidelines for the international MGT community. The findings presented here provide further support for the need to consider the application of the Organisation for Economic Cooperation and Development (OECD) Guidelines and the establishment of compatible accreditation programs or eq...Continue Reading

References

Mar 10, 1999·JAMA : the Journal of the American Medical Association·M M McGovernR Keenlyside
Jul 1, 1999·Health Affairs·G F Anderson, J P Poullier
Jun 7, 2003·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Suzanne M CoxIra M Lubin
Oct 8, 2004·Nature Biotechnology·Dolores IbarretaElisabeth Dequeker
Jun 19, 2007·Community Genetics·Margaret M McGovernElettra Ronchi

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Citations

Nov 26, 2009·Genetic Testing and Molecular Biomarkers·Bruno DallapiccolaRita Mingarelli
Aug 1, 2009·BMC Health Services Research·Fiona A MillerSuzanne Kamel-Reid
Jul 22, 2009·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Ann F ChouJohn J Mulvihill
Jun 11, 2017·Blood·Jonathan M Marron, Steven Joffe
Mar 21, 2009·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Jaekyu ShinTaimour Y Langaee
Jun 4, 2014·The Journal of Clinical Endocrinology and Metabolism·Jacques W M LendersWilliam F Young
Mar 1, 2009·Personalized Medicine·Jaekyu Shin, Steven R Kayser
Dec 5, 2020·Hematology·Jonathan M Marron

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