PMID: 2504259Jan 1, 1989Paper

Molecular genetics of Alzheimer's disease and the amyloid beta peptide precursor gene

Annals of Medicine
R E Tanzi

Abstract

Alzheimer's disease is a neurodegenerative disorder characterized by global cognitive decline. An autopsy of the Alzheimer patient's brain reveals two major neuropathological lesions: neurofibrillary tangles, and amyloid deposits in the form of senile plaques and cerebrovascular accumulations. While tangles appear to be a universal hallmark of dying neurons in several neurodegenerative diseases, amyloid plaques occur in only three conditions including Alzheimer's disease, Down syndrome, and to a limited extent, normal aging. The frequency of senile plaques appears to correlate well with the degree of dementia in the Alzheimer's patient. It remains unclear, however, whether amyloid formation represents one of the final stages of a long neuropathological process in the brain, or initially participates in promoting neuronal dysfunction. To address this question, we have isolated the gene encoding the precursor of the principle component of the plaque, the amyloid beta peptide. We have mapped this gene to chromosome 21, the same chromosome in which we have detected linkage between anonymous DNA markers and the familial form of Alzheimer's disease. Employing direct genetic linkage analysis, we have shown that the amyloid gene and th...Continue Reading

References

Aug 1, 1988·Genomics·R E TanziJ F Gusella
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·N K RobakisH M Wisniewski
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·C L MastersK Beyreuther
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M L CohenS G Younkin
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G A HigginsM C Wilson
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D A LewisJ H Morrison
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·D A KirschnerD J Selkoe
Dec 15, 1986·Biochemical and Biophysical Research Communications·E M CastañoB Frangione
Aug 16, 1984·Biochemical and Biophysical Research Communications·G G Glenner, C W Wong

❮ Previous
Next ❯

Citations

Oct 16, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anne B Young
Jan 1, 2004·Nonlinearity in Biology, Toxicology, Medicine·V W Pentreath, C Mead
Sep 8, 2018·PloS One·Chera L MaaroufGeidy E Serrano
Mar 10, 2010·Journal of Lipid Research·You-Hai XuGregory A Grabowski
Apr 27, 2016·The Cochrane Database of Systematic Reviews·Nolwenn PoquetChristopher G Maher
May 10, 2020·Periodontology 2000·Angela R KamerMony J de Leon
Mar 5, 2011·Journal of Neuroscience Research·J Gregor SutcliffeBrian S Hilbush
Oct 23, 2019·JAMA : the Journal of the American Medical Association·Zoe ArvanitakisDavid A Bennett

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.