PMID: 2496037Jan 1, 1989Paper

Molecular genetics of human immune responsiveness to Lolium perenne (rye) allergen, Lol p III

International Archives of Allergy and Applied Immunology
A A AnsariD G Marsh

Abstract

Lol p II and III are each about 11-kD protein allergens from the pollen of Lolium perenne (rye grass). We have found that human immune responses (IgE and IgG antibodies) to both proteins are significantly associated with HLA-DR3. In addition, the two proteins are cross-reactive with the antibodies in many human sera (about 84% human sera showed the cross-reactivity). We have determined greater than 90% of the amino acid sequences of the two proteins and found that they are at least 54% homologous. Berzofsky found that 75% of the 23 known T cell sites in various proteins had an amphipathic structure. Our analysis by the same method showed that both Lol p II and III have a major region of amphipathicity (at residues 61-67, Lol p III numbering) which might contain sites for binding to an Ia molecule and a T cell receptor. This region is identical between Lol p II and III, except for an Arg-Lys substitution, and could account, in part, for the DR3 association with responsiveness to both molecules. An interesting difference between the two proteins is that immune response to Lol p III is associated with DR5 (in addition to DR3), whereas no DR5 association is found in the case of Lol p II. One possibility is that Lol p III has an add...Continue Reading

Citations

Jun 17, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Arnd PetersenWolf-Meinhard Becker
Nov 1, 1990·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M Ricci, O Rossi
Sep 1, 1990·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P SriramaraoP V Rao
Sep 1, 1994·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M Ricci

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