Molecular genetics of melanocytic neoplasia: practical applications for diagnosis

Pathology
Boris C Bastian

Abstract

Pathology is the gold standard for the diagnosis of skin cancer. However, despite morphological criteria that have been constantly refined, there remain areas in which histopathological analysis does not permit an unequivocal diagnosis. Among these, problems most frequently arise with melanocytic lesions. This article reviews recent molecular studies that have revealed differences in the pattern of chromosomal aberrations between naevi and melanoma that could become relevant as adjunctive diagnostic methods in the future.

References

Nov 4, 1996·International Journal of Cancer. Journal International Du Cancer·A SpatzM Prade
Jul 1, 1997·International Journal of Dermatology·R Jackson
Aug 10, 2000·Neoplasia : an International Journal for Oncology Research·R D RamirezJ W Shay
Jun 26, 2001·The Oncologist·M J Mauro, B J Druker
Mar 21, 2002·Nature Reviews. Cancer·N F Mathon, A C Lloyd
Nov 26, 2002·Nature Genetics·Pamela M PollockPaul S Meltzer
May 21, 2003·Archives of Dermatology·Boris C Bastian
Jan 8, 2004·The Journal of Investigative Dermatology·Amir S YazdiChristian A Sander
Apr 28, 2004·The American Journal of Pathology·Janet L MaldonadoBoris C Bastian

❮ Previous
Next ❯

Citations

May 11, 2012·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·M Braun-Falco, T Ruzicka
Mar 12, 2013·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·D P JoyceA D K Hill
Feb 22, 2005·Lancet·John F ThompsonRichard F Kefford
Jul 28, 2010·Journal of the National Cancer Institute·Vasileia-Ismini AlexakiAlain Mauviel
Jun 11, 2011·Biomarkers in Medicine·Konstantinos LinosJ Andrew Carlson
Jul 22, 2006·Advances in Anatomic Pathology·Wolter J Mooi, T Krausz
Dec 20, 2011·American Journal of Surgery·Sarah J Hill, Keith A Delman
Mar 15, 2011·Cellular Signalling·Chengxin LiJingwu Xie
Nov 26, 2009·The Medical Clinics of North America·Carlos RicottiClay J Cockerell
Dec 5, 2008·Experimental Dermatology·Markus Braun-FalcoWolfgang Weyers
Oct 20, 2011·Histopathology·Rebecca SenettaDaniela Massi
May 26, 2009·Hematology/oncology Clinics of North America·Adriano Piris, Martin C Mihm
Nov 19, 2005·Seminars in Oncology Nursing·Frank L Meyskens, Patricia Tully
Oct 20, 2009·Seminars in Oncology·John M KirkwoodLeonard S Sender

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.