Molecular Genetics of Pigment Dispersion Syndrome and Pigmentary Glaucoma: New Insights into Mechanisms

Journal of Ophthalmology
Adrian A Lahola-Chomiak, Michael A Walter

Abstract

We explore the ideas and advances surrounding the genetic basis of pigment dispersion syndrome (PDS) and pigmentary glaucoma (PG). As PG is the leading cause of nontraumatic blindness in young adults and current tailored interventions have proven ineffective, a better understanding of the underlying causes of PDS, PG, and their relationship is essential. Despite PDS being a subclinical disease, a large proportion of patients progress to PG with associated vision loss. Decades of research have supported a genetic component both for PDS and conversion to PG. We review the body of evidence supporting a genetic basis in humans and animal models and reevaluate classical mechanisms of PDS/PG considering this new evidence.

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Citations

Sep 11, 2019·Clinical & Experimental Ophthalmology·Tanner J FergusonJohn P Berdahl
Nov 21, 2020·BMC Ophthalmology·Igor Šivec Trampuž
Apr 20, 2021·Klinische Monatsblätter für Augenheilkunde·Matthias Nobl, Marc Mackert

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