PMID: 9183548Apr 1, 1997Paper

Molecular genetics of plasma cholesteryl ester transfer protein

Current Opinion in Lipidology
S YamashitaY Matsuzawa

Abstract

Plasma cholesteryl ester transfer protein facilitates the transfer of cholesteryl ester from HDL to apolipoprotein B-containing lipoproteins, and is a key protein in the reverse cholesterol transport system. The importance of plasma cholesteryl ester transfer protein in lipoprotein metabolism was highlighted by the discovery of deficient individuals with a marked hyper-HDL-cholesterolemia. Cholesteryl ester transfer protein deficiency causes various abnormalities in the concentration, composition, and functions of both HDL and LDL. Its significance in atherosclerosis is still controversial. However, in-vitro evidence shows large cholesteryl ester-rich HDL particles in cholesteryl ester transfer protein deficiency are defective in cholesterol efflux. Recent epidemiological studies have demonstrated an increased incidence of coronary atherosclerosis in deficient patients. The current review will also focus on the molecular genetics of the protein.

Citations

Dec 21, 2000·Current Atherosclerosis Reports·J M Ordovas, E J Schaefer
Oct 6, 2000·Clinica Chimica Acta; International Journal of Clinical Chemistry·S HirayamaY Saito
Nov 7, 1998·Clinical Chemistry and Laboratory Medicine : CCLM·S A HillM J McQueen
Jan 5, 2001·Clinical Chemistry and Laboratory Medicine : CCLM·J M Ordovas
Jun 22, 2000·Biochemical and Biophysical Research Communications·A MatsuyamaY Matsuzawa
Jul 25, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Kostas C SiamopoulosAlexandros D Tselepis
Jul 17, 2004·Journal of Atherosclerosis and Thrombosis·Makoto NaganoYuji Matsuzawa
Jun 2, 2010·Journal of Atherosclerosis and Thrombosis·Shizuya YamashitaMakoto Nishida
Aug 17, 2000·Current Opinion in Lipidology·A InazuH Mabuchi
Nov 22, 2000·Current Opinion in Lipidology·K HiranoY Matsuzawa

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