Molecular genetics of the BK virus

Advances in Experimental Medicine and Biology
Christopher L Cubitt

Abstract

The BK Virus (BKV) genome is a double-stranded, circular DNA molecule with genetic organization similar to other polyomaviruses, and high homology to JC Virus (JCV) and SV40. The archetypal form of BKV noncoding regulatory region (NCRR) is the infectious form of BKV that replicates in the urothelium and is excreted in the urine. Rearranged forms of the NCRR are found in kidney and other tissues often in association with disease. BKV strains can be assigned to genotype/serotype groups based on sequence variation in the VP1 gene. Sequencing of the complete genomes from patient samples will enhance BKV phylogenetic studies and identify genotypic differences and naturally occurring mutations in BKV that may correlate with incidence and/or severity of a disease. This chapter is a review of the molecular genetics of the BK virus in respect to BKV disease.

Citations

Jul 15, 2016·Acta Neuropathologica Communications·Armine DarbinyanNadejda M Tsankova
Nov 4, 2017·Viruses·Francois HelleGilles Duverlie
Mar 17, 2017·Clinical Microbiology Reviews·George R AmbalathingalRajiv Khanna
Nov 28, 2008·Journal of Virology·Mengxi JiangMichael J Imperiale
Jul 25, 2019·International Journal of Molecular Sciences·Jeanne K DuShane, Melissa S Maginnis
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Jun 19, 2008·Virology·Johanna R Abend, Michael J Imperiale
Sep 4, 2010·Journal of Virological Methods·Mark E SeamoneDaniel A Muruve

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