PMID: 18407160Sep 1, 1993Paper

Molecular genetics of thyroid cancer

Trends in Endocrinology and Metabolism : TEM
D Wynford-Thomas

Abstract

Tumors of the human thyroid follicular cell demonstrate multiple "routes" and multiple stages of development, offering an unparalleled opportunity for correlating clinicopathologic tumor behavior with the underlying molecular genetic abnormalities. This review summarizes the clinical and experimental evidence supporting the causal role of five key genes in thyroid oncogenesis, namely, the oncogenes ras, gsp, ret, and trk, and the tumor-suppressor gene TP53. The nature of the somatic mutations is described and the likely mechanisms discussed by which they perturb cellular growth signal transduction to produce particular pathologic phenotypes. A model of thyroid oncogenesis is presented that suggests that the pattern of tumor development is determined by the nature of the initiating oncogenic event.

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Citations

Oct 1, 1996·The Journal of Pathology·D Wynford-Thomas
Jan 15, 1996·Molecular and Cellular Endocrinology·C J JonesD Wynford-Thomas
Apr 15, 2008·Trends in Endocrinology and Metabolism : TEM·J Robbins, A B Schneider
Mar 29, 2001·Thyroid : Official Journal of the American Thyroid Association·F PedrinolaG Medeiros-Neto
Feb 1, 1997·Thyroid : Official Journal of the American Thyroid Association·K C Loh
Mar 1, 1994·Histopathology·G T Williams, D Wynford-Thomas
Aug 12, 1998·Journal of Endocrinological Investigation·P HarrerM Derwahl
Apr 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D Wynford-Thomas
Jan 26, 2010·International Journal of Surgery·Rajeev ParameswaranGregory Paul Sadler
Apr 6, 2001·Baillière's Best Practice & Research. Clinical Endocrinology & Metabolism·F MorettiA Pontecorvi
Jan 10, 2013·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Yu LunJian Zhang
Jan 27, 2012·The Journal of Clinical Endocrinology and Metabolism·Emilio Fiore, Paolo Vitti

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