Molecular grade (FGFR3/MIB-1) and EORTC risk scores are predictive in primary non-muscle-invasive bladder cancer

European Urology
Bas W G van RhijnTheo H van der Kwast

Abstract

The European Organization for Research and Treatment of Cancer (EORTC) risk scores are not validated in an independent patient population. Molecular grade (mG) based on fibroblast growth factor receptor 3 (FGFR3) gene mutation status and MIB-1 expression was proposed as an alternative to pathologic grade in bladder cancer (BCa) [1]. To validate the EORTC risk score and to determine its relation to mG in a series with long-term follow-up as well as to determine reproducibility of pathologic grade and mG. In this multicenter study, we included 230 patients with primary non-muscle-invasive BCa (NMIBC). Four uropathologists reviewed the slides. FGFR3 mutation status was examined by two assays. MIB-1 was assessed by immunohistochemistry. The EORTC risk scores for recurrence and progression were determined. Multivariable analyses were used to find prognostic factors. Median follow-up was 8.62 yr (interquartile range: 6.6-11.8). FGFR3 mutations were significantly related to favorable disease parameters, whereas altered MIB-1 was frequently seen with pT1, high grade, and high EORTC risk scores. EORTC risk scores were significant in multivariable analyses for recurrence and progression. In multivariable analyses for progression and dise...Continue Reading

References

Jun 8, 2001·The American Journal of Pathology·C BillereyF Radvanyi
May 14, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bas W G van RhijnEllen C Zwarthoff
Nov 10, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Karsten ZiegerTorben Falck Ørntoft
Nov 10, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Johanna M M van OersEllen C Zwarthoff
Jan 10, 2006·Urology·Ziya KirkaliJeff Weider
Aug 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Silvia HernándezFrancisco X Real
Nov 11, 2006·European Urology·Gregory T MacLennanLiang Cheng
Jan 16, 2007·The Journal of Urology·Shahrokh F ShariatYair Lotan
Jan 31, 2008·Neoplasia : an International Journal for Oncology Research·Kerstin JunkerArndt Hartmann
May 13, 2008·European Urology·Marko BabjukUNKNOWN European Association of Urology (EAU)

❮ Previous
Next ❯

Citations

Feb 23, 2012·Current Urology Reports·Michael RinkShahrokh F Shariat
Jul 25, 2012·Current Opinion in Urology·Maria FrantziAntonia Vlahou
Jul 31, 2012·Current Opinion in Urology·Sima P Porten, Matthew R Cooperberg
Aug 18, 2012·Advances in Urology·Erica di MartinoMargaret A Knowles
Mar 31, 2012·Archives of Pathology & Laboratory Medicine·George J Netto, Liang Cheng
Aug 13, 2011·Der Urologe. Ausg. A·H Rübben, F Vom Dorp
Sep 14, 2014·Urologic Oncology·Bas W G van RhijnLambertus A Kiemeney
Jul 19, 2014·Critical Reviews in Clinical Laboratory Sciences·Francesca SanguedolceLuigi Cormio
Jun 9, 2015·Critical Reviews in Clinical Laboratory Sciences·Francesca SanguedolceLuigi Cormio
Dec 24, 2014·International Journal of Molecular Sciences·Jahan Miremami, Natasha Kyprianou
Dec 18, 2013·Urologic Oncology·Evanguelos XylinasShahrokh F Shariat
Dec 18, 2013·Seminars in Diagnostic Pathology·George J Netto
Apr 2, 2013·The Urologic Clinics of North America·Rianne J M LammersJ Alfred Witjes
Oct 23, 2012·European Urology·Mahul B AminUNKNOWN International Consultation on Urologic Disease-European Association of Urology Consultation on Bladder Cancer 2012
Dec 1, 2012·Surgical Pathology Clinics·George J Netto
Oct 23, 2012·European Urology·Ashish M KamatUNKNOWN International Consultation on Urologic Disease-European Association of Urology Consultation on Bladder Cancer 2012
Sep 24, 2015·Nature Reviews. Urology·Kim E M van KesselEllen C Zwarthoff
Nov 29, 2015·The Urologic Clinics of North America·George J Netto, Laura J Tafe
Nov 26, 2010·International Journal of Urology : Official Journal of the Japanese Urological Association·Richard J Sylvester
Nov 28, 2015·Surgical Pathology Clinics·James P Solomon, Donna E Hansel
Apr 21, 2011·Scandinavian Journal of Urology and Nephrology·Sigurdur GudjónssonFredrik Liedberg
Feb 25, 2015·European Urology·Luis A KluthShahrokh F Shariat
Nov 29, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Bas W G van RhijnTheo H van der Kwast
Apr 14, 2015·BioMed Research International·Enrique Redondo-GonzalezJuan Manuel Corchado
Feb 16, 2013·Seminars in Cancer Biology·Erik L BrincksThomas S Griffith
Mar 13, 2014·Urologic Oncology·Malte BöhmOliver W Hakenberg
Nov 15, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Willemien BeukersEllen C Zwarthoff
Oct 6, 2014·Urologic Oncology·Pierre Olivier BossetThierry Lebret
Jul 7, 2016·Future Oncology·Erica di MartinoMargaret A Knowles

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.