Molecular heterogeneity in adjacent cells in triple-negative breast cancer

Breast Cancer : Targets and Therapy
Michael L HuebschmanEugene P Frenkel

Abstract

This study interrogates the molecular status of individual cells in patients with triple-negative breast cancers and explores the molecular identification and characterization of these tumors to consider the exploitation of a potential-targeted therapeutic approach. Hyperspectral immunologic cell by cell analysis was applied to touch imprint smears obtained from fresh tumors of breast cancer patients. Cell by cell analysis confirms significant intratumoral molecular heterogeneity in cancer markers with differences from polymerase chain reaction marker reporting. The individual cell heterogeneity was recognized in adjacent cells examined with panels of ten molecular markers in each single cell and included some markers that are considered to express "stem-cell" character. In addition, heterogeneity did not relate either to the size or stage of the primary tumor or to the site from within the cancer. There is a very significant molecular heterogeneity when "adjacent cells" are examined in triple-negative breast cancer, thereby making a successful targeted approach unlikely. In addition, it is not reasonable to consider that these changes will provide an answer to tumor dormancy.

Citations

Mar 24, 2016·Pharmacology & Therapeutics·Zhuo Li, Yibin Kang
Jul 30, 2019·PloS One·Gil CovarrubiasEfstathios Karathanasis
Oct 20, 2018·PloS One·Gil CovarrubiasEfstathios Karathanasis
May 8, 2018·Frontiers in Cell and Developmental Biology·Alexander E Davies, John G Albeck

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
exome sequencing

Related Concepts

Related Feeds

Breast Cancer Triple-N

Breast cancer cells have receptors for estrogen, progesterone, HER2 receptors (also called ERBB2). Triple-negative breast cancers do not have any of these receptors. Here are the latest discoveries pertaining to triple-negative breast cancers.

Related Papers

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Clinical Journal of Oncology Nursing
Debra L Winkeljohn
International Journal of Breast Cancer
Quyen D ChuThelma Hurd
La Revue du praticien
Anne Vincent-Salomon
© 2021 Meta ULC. All rights reserved