Abstract
B-lineage diffuse large cell lymphoma (B-DLCL) arising de novo is characterized by a marked degree of clinical heterogeneity. To determine whether or not the clinical heterogeneity of de novo B-DLCL is reflected by heterogeneity in the molecular features of these tumors, we investigated the pattern of distribution of several genetic lesions in 70 cases of de novo B-DLCL at diagnosis. The panel of genetic lesions tested comprised the molecular alterations most frequently detected in B-DLCL, including rearrangements of BCL2, BCL6, and MYC as well as deletions of 6q and mutations of TP53. One or more genetic lesions were detected in 39/70 cases of B-DLCL. Isolated structural alterations of BCL2, BCL6, 6q or TPS3 were detected in 8/70, 10/70, 11/70, and 3/70 cases, respectively. No isolated MYC lesions were detected. Six cases carried different combinations of two genetic lesions, including lesions of BCL2 + BCL6 (1 case), BCL2 + MYC (1 case), BCL2 + 6q (2 cases), or BCL6 + 6q (2 cases). One case had accumulated three genetic lesions, namely a rearrangement of BCL2 and BCL6 and a mutation of TPS3. Overall, these data show that multiple distinct patterns of genetic lesions may associate with de novo B-DLCL, indicating that the molec...Continue Reading
References
Feb 25, 1992·Nucleic Acids Research·A SerraG Saglio
Sep 1, 1991·Genomics·G VergnaudV Lauthier
Jul 5, 1991·Science·M HollsteinC C Harris
Jun 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·G GaidanoR Dalla-Favera
Jun 1, 1990·Pathology, Research and Practice·L XerriP Chuchana
Dec 7, 1989·Nature·J M NigroP Devilee
Nov 1, 1989·Genomics·M OritaK Hayashi
Jun 1, 1989·British Journal of Haematology·K OffitR S Chaganti
Jul 1, 1986·The Journal of Experimental Medicine·M L ClearyJ Sklar
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A NeriR Dalla-Favera
Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·Y Tsujimoto, C M Croce
Jul 18, 1985·Nature·K A SiminovitchS J Korsmeyer
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·S J KorsmeyerP Leder
Jul 1, 1983·Analytical Biochemistry·A P Feinberg, B Vogelstein
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·R Dalla-FaveraC M Croce
Jun 1, 1995·British Journal of Haematology·G Gaidano, A Carbone
Dec 16, 1994·Science·Y ChangP S Moore
Jan 1, 1994·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R Dalla-FaveraR S Chaganti
Jul 14, 1994·The New England Journal of Medicine·K OffitA Rosenbaum
Oct 29, 1993·Science·B H YeR Dalla-Favera
Jan 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S C TangS Poppema
Dec 19, 1995·Proceedings of the National Academy of Sciences of the United States of America·A MigliazzaR Dalla-Favera
Citations
Jan 10, 1998·The Journal of Pathology·E PescarmonaF Le Coco
Jan 19, 1999·Genes, Chromosomes & Cancer·G GaidanoA Carbone
Dec 29, 1999·Genes, Chromosomes & Cancer·G GaidanoA Carbone
Aug 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G Gaidano, A Carbone
Feb 6, 2004·Blood Cells, Molecules & Diseases·María Fernanda NoriegaIrma Slavutsky
Jun 24, 2005·Leukemia·R SchmitzR Küppers
Sep 12, 1998·British Journal of Haematology·A CarboneG Gaidano
May 8, 1999·British Journal of Haematology·W Y AuD E Horsman
Aug 27, 2002·Journal of Clinical Pathology·L LeonciniP Tosi
Aug 28, 1998·Leukemia & Lymphoma·G GaidanoA Carbone
May 16, 2000·Cancer Investigation·B H Ye
Jul 28, 2004·The American Journal of Pathology·Tiemo KatzenbergerM Michaela Ott
Jul 21, 2009·Leukemia Research·Kazumi HagiwaraHirokazu Nagai
Jun 6, 2002·American Journal of Clinical Pathology·Mar BellidoJosep F Nomdedéu
May 2, 2006·Human Pathology·Anneke G Bosga-BouwerSibrand Poppema
Feb 20, 2004·Hematology·Davide Rossi, Gianluca Gaidano
Oct 23, 1997·Hematology/oncology Clinics of North America·R D Gascoyne
Feb 5, 2013·Critical Reviews in Oncology/hematology·Maurizio MartelliStefano A Pileri
Jan 23, 2004·Oncogene·Saritha KusamAlexander L Dent
Feb 13, 2002·Leukemia·U VitoloG Gaidano
Mar 16, 2002·Blood·James Z HuangWing C Chan
Feb 11, 2000·Brain Pathology·T WeberP Lichter
Dec 12, 1997·American Journal of Hematology·G GaidanoG Saglio
Apr 30, 2016·Traffic·Samantha J SpratleyJanet E Deane