PMID: 2494662Apr 1, 1989Paper

Molecular heterogeneity of gamma delta T-cell antigen receptors expressed by CD4- CD8- T-cell clones from normal donors: both disulfide- and non-disulfide-linked receptors are delta TCS1+

Proceedings of the National Academy of Sciences of the United States of America
H SekiC D Platsoucas

Abstract

We investigated the molecular heterogeneity of gamma delta T-cell antigen receptors (TCR) expressed on T-cell clones generated from peripheral blood lymphocytes of normal donors. Extensive molecular heterogeneity was seen at the gamma-chain level and, to a lesser extent, at the delta-chain level. Both disulfide and non-disulfide gamma delta TCR were found and use different gamma chains with similar molecular masses (range, 41-43 kDa). In contrast, gamma chains of 55-60 kDa, which are expressed on T-cell lines derived from the peripheral blood of patients with immunodeficiency disorders, were not found on T-cell clones derived from the peripheral blood of normal donors. delta chains expressed on these T-cell clones had a molecular mass of 37 kDa and were either disulfide or nondisulfide linked. Significant delta-chain heterogeneity was identified in these clones using the anti-delta TCS1 and the anti-TCR delta 1 monoclonal antibodies. All clones tested were TCR delta 1+, whereas only 25% of the clones were delta TCS1+. The anti-delta TCS1 monoclonal antibody stained and immunoprecipitated both disulfide- and non-disulfide-linked gamma delta TCRs from different T-cell clones from normal donors.

References

Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·C G IoannidesC D Platsoucas
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M P LefrancT H Rabbitts
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A WeissD Crommie
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May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·Y YanagiT W Mak
Jul 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·C D Platsoucas, R A Good

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Citations

Jun 1, 1991·Cancer Metastasis Reviews·C D Platsoucas
Jan 1, 1995·Immunologic Research·L I Sakkas, C D Platsoucas
Jan 1, 1994·Immunologic Research·L I SakkasC D Platsoucas
Sep 1, 1990·Research in Immunology·R L BolhuisE Braakman
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M LondeiM Feldmann
Apr 23, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Song LuChris D Platsoucas

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