Molecular heterogeneity of the cDNA encoding a 74-kDa regulatory subunit (B" or delta) of human protein phosphatase 2A

FEBS Letters
O TanabeM Takeda

Abstract

Two cDNAs for possible splicing variants of a 74-kDa regulatory subunit (B" or delta) of human protein phosphatase 2A, were isolated. These variants were identified from human cerebral cortex by library screening and PCR, and designated delta1 and delta3 isoforms, while the previously reported isoform [Tanabe et al. (1996) FEBS Lett. 379, 107-1111 was designated delta2. Compared with the delta2 isoform, the delta1 isoform contained a 32-residue insertion beginning at residue 84, and consisted of 602 amino acids in all. The delta3 isoform lacked a 74-residue sequence corresponding to residues 1083 of the delta2 isoform, and consisted of 496 amino acids. Using isoform-specific antipeptide antisera, the 74-kDa subunit (B" or delta) originally purified from human erythrocytes was identified as the delta1 isoform.

References

Jan 1, 1989·Annual Review of Biochemistry·P Cohen
Nov 3, 1995·The Journal of Biological Chemistry·B McCright, D M Virshup
Mar 1, 1996·The Journal of Biological Chemistry·M A TehraniC Kamibayashi

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Citations

Jan 25, 2005·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Natsuko NakadaEi Kawahara
Aug 3, 2013·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Shu-Hong Sheng, Hui-Li Zhu
Mar 22, 2001·Experimental Neurology·V Vogelsberg-RagagliaV M Lee

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