Molecular heterogeneity of tumor endothelium

Cell and Tissue Research
W C Aird

Abstract

Tumors depend on a vascular supply for their growth. Tumor blood vessels, which are derived from normal tissue vasculature, display a markedly abnormal phenotype. Tumor endothelial properties are highly varied in space and time. An important goal is to delineate the range of phenotypes in tumor endothelium and to identify tumor endothelial-specific molecular signatures. This information should lead to a more complete understanding of the mechanisms of tumor growth, the discovery of new therapeutic targets, and the development of biomarkers for diagnosis and surveillance. The goals of this review are to outline recent advances in dissecting tumor endothelial-cell-specific gene expression, to address mechanisms of phenotypic heterogeneity in tumor vascular beds, and to discuss the therapeutic implications of these findings.

References

Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·W J RettigL J Old
Nov 18, 1971·The New England Journal of Medicine·J Folkman
Aug 12, 1971·The New England Journal of Medicine·J Folkman
Nov 1, 1982·British Journal of Cancer·J Denekamp, B Hobson
Feb 14, 1998·Cancer Letters·S M HellwigA W Griffioen
Oct 20, 1998·The American Journal of Pathology·W G RobertsG E Palade
Jun 3, 2000·Annual Review of Immunology·E Ruoslahti, D Rajotte
Aug 19, 2000·Science·B St CroixK W Kinzler
Sep 23, 2000·Nature·P Carmeliet, R K Jain
Mar 20, 2001·The Journal of Clinical Investigation·E BoyeJ Bischoff
Feb 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Markus Essler, Erkki Ruoslahti
Mar 14, 2002·The American Journal of Pathology·Shunichi MorikawaDonald M McDonald
Jun 8, 2002·Nature Medicine·Pirjo LaakkonenErkki Ruoslahti
Nov 7, 2002·In Vitro Cellular & Developmental Biology. Animal·Ronald E UngerC James Kirkpatrick
Apr 24, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Benedetta BussolatiGiovanni Camussi
Dec 12, 2003·Cancer Cell·Jason A HoffmanErkki Ruoslahti
Jul 28, 2004·The American Journal of Pathology·Stephen L MaddenKevin A Walter
Nov 3, 2004·Cancer Research·Belinda S ParkerStephen L Madden
Nov 19, 2004·Cancer Research·Kyoko HidaMichael Klagsbrun
Jan 22, 2005·Current Opinion in Genetics & Development·Peter BalukDonald M McDonald
Feb 25, 2005·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Yun C YungVictor Tse
Mar 12, 2005·World Journal of Gastroenterology : WJG·K A RmaliW G Jiang
May 17, 2005·Brain Research. Molecular Brain Research·Hyun Kyoung LeeHwan Tae Park
Jun 2, 2005·Proceedings of the National Academy of Sciences of the United States of America·Nina JendreykoCarlos F Barbas
Jun 2, 2005·Nature Reviews. Cancer·Gillian M TozerBruce C Baguley
Jun 2, 2005·Nature Reviews. Cancer·Dario Neri, Roy Bicknell
Jul 26, 2005·Biochimica Et Biophysica Acta·Judy R van Beijnum, Arjan W Griffioen
Sep 8, 2005·Circulation·Lianglin ZhangErkki Ruoslahti
Nov 10, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Eleanor B Carson-WalterKevin A Walter
Dec 16, 2005·Nature·Napoleone Ferrara, Robert S Kerbel
Dec 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Carmen M BarnésSteven J Fishman
Dec 31, 2005·Proceedings of the National Academy of Sciences of the United States of America·Philippe ValadonJan E Schnitzer
Feb 4, 2006·Circulation Research·William C Aird

❮ Previous
Next ❯

Citations

Nov 19, 2008·Cell and Tissue Research·E DejanaH Wolburg
Feb 9, 2012·Cold Spring Harbor Perspectives in Medicine·William C Aird
Mar 7, 2012·Cold Spring Harbor Perspectives in Medicine·Andrew C Dudley
Jan 21, 2011·Science Translational Medicine·Joseph W FransesElazer R Edelman
Dec 7, 2011·Cancer Research·Joseph W Franses, Elazer R Edelman
Jul 30, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Andrew C Dudley, Michael Klagsbrun
Jul 30, 2015·Upsala Journal of Medical Sciences·Lena Claesson-Welsh
Aug 4, 2011·Journal of Thrombosis and Haemostasis : JTH·B Ho-Tin-NoéD D Wagner
May 17, 2014·Platelets·Tony G WalshMichael C Berndt
Jan 25, 2020·Advanced Healthcare Materials·Katharine R BittnerShelly R Peyton
Apr 9, 2020·Cell Communication and Signaling : CCS·Roghayyeh BaghbanPeyman Zare
Sep 12, 2015·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Keisuke Omori, Takahisa Murata
Jul 28, 2018·Frontiers in Bioengineering and Biotechnology·Si ChenP I Imoukhuede
May 8, 2020·International Journal of Molecular Sciences·Dorcas Akuba-Muhyia AnnanKyoko Hida
Nov 1, 2010·Experimental and Therapeutic Medicine·Suely NonogakiM Mitzi Brentani
Nov 15, 2018·International Journal of Molecular Sciences·Nicky D'HaeneIsabelle Salmon
Jan 5, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Susan E BatesGiuseppe Giaccone

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Medical Electron Microscopy : Official Journal of the Clinical Electron Microscopy Society of Japan
Katsuhiko EnomotoQinchang Li
American Journal of Physiology. Heart and Circulatory Physiology
Tomomi KambaDonald M McDonald
© 2022 Meta ULC. All rights reserved