PMID: 2111855May 1, 1990Paper

Molecular homology and DNA hybridization

Journal of Molecular Evolution
A H Bledsoe, F H Sheldon

Abstract

We reviewed the concept of homology, which can broadly be defined as a correspondence between characteristics that is caused by continuity of information (Van Valen 1982). The concept applies widely in molecular biology when correspondence is taken to mean a genetic relationship resulting from a unique heritable modification of a feature at some previous point in time. Such correspondence can be established for features within a single organism as well as between organisms, making paralogy a valid form of molecular homology under this definition. Molecular homology can be recognized at a variety of organizational levels, which are interdependent. For example, the recognition of homology at the site level involves a statement of homology at the sequence level, and vice versa. This hierarchy, the potential for nonhomologous identity at the site level, and such processes as sequence transposition combine to yield a molecular equivalent to complex structural homology at the anatomical level. As a result, statements of homology between heritable units can involve a valid sense of percent homology. We analyzed DNA hybridization with respect to the problems of recognizing homology and using it in phylogenetic inference. Under a model ...Continue Reading

References

Jun 8, 1979·Science·E H Davidson, R J Britten
Mar 1, 1990·Journal of Molecular Evolution·C W Schmid, J Marks
Sep 1, 1989·The Quarterly Review of Biology·M Springer, C Krajewski
Jan 1, 1987·Journal of Molecular Evolution·J Felsenstein
Jan 1, 1988·Acta Biotheoretica·F Aboitiz
Jan 1, 1968·Annual Review of Biochemistry·C Nolan, E Margoliash
Dec 5, 1973·Journal of Molecular Biology·T I BonnerR J Britten
Jun 1, 1968·Systematic Zoology
Sep 1, 1970·Systematic Zoology·L A Johnson
Jun 1, 1971·The Quarterly Review of Biology·R J Britten, E H Davidson
Jan 20, 1967·Science·W M Fitch, E Margoliash
Oct 11, 1969·Nature·C D LairdB J McCarthy
Jun 1, 1970·Systematic Zoology·W M Fitch
Mar 1, 1966·Journal of Molecular Biology·W M Fitch
Jan 1, 1984·Journal of Molecular Evolution·C G Sibley, J E Ahlquist
Apr 25, 1983·Journal of Molecular Biology·H T JacobsE H Davidson
Sep 1, 1982·Journal of Morphology·L M Van Valen
Dec 1, 1964·Proceedings of the National Academy of Sciences of the United States of America·E K BAUTZ, F A BAUTZ
Mar 1, 1975·Evolution; International Journal of Organic Evolution·G F Shields, N A Straus
Sep 1, 1967·Evolution; International Journal of Organic Evolution·L L Cavalli-Sforza, A W F Edwards
Jul 1, 1989·Evolution; International Journal of Organic Evolution·Gregory A Wray, David R McClay
Sep 1, 1989·Evolution; International Journal of Organic Evolution·G P Wagner

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.